Cartilage oligomeric matrix expression in patients with chronic hepatitis C [Abstract in English]

Jaqueline Costa Coelho, Mirian Cohen, Ana Lígia Bender, Carlos Kupski

Abstract


Purpose: Chronic hepatitis C is an insidiously
progressive disease, in witch repeated assessment of liver
histology is required. Various serum markers have now
been introduced. Cartilage oligomeric matrix protein
(COMP) is the fifth member of the trombospondin family
of extra cellular calcium-binding proteins. It was initially
isolated and characterized in cartilage tissue. One study
investigated the expression of COMP in normal liver, liver
cirrhosis and hepatocellular carcinoma tissues. Our present
aim was to asses the serum COMP in patients with chronic
hepatitis C.

Methods and results: Serum levels of COMP were
measured in 10 patients with chronic hepatitis C (cases)
and 100 healthy patients (controls). The difference between
two groups was not statistical significant and not related
to clinical stage of liver fibrosis, virus genotypes, platelets
or transaminases alterations.

Conclusion: COMP was absent or rarely expressed in
liver cirrhosis tissues. Others serum fibrotic markers have
now been studied.

KEY WORDS: BIOLOGICAL MARKERS; THROMBOSPONDINS;
HEPATITIS C, CHRONIC; LIVER CIRRHOSIS.



e-ISSN: 1980-6108 | ISSN-L: 1806-5562


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