The role of regular physical exercise for enhancement of long-term memory in the elderly: a review of recent evidences

Helen Lidiane Schimidt, Pâmela Billig Mello Carpes, Felipe Pivetta Carpes


Aims: We performed a systematic review of recent literature to discuss the role of physical exercise on cognition of the elderly, especially long-term memory (LTM). Source of data: The articles were sought in scientific journals indexed in Medline through PubMe and PubMed Central websites. In the final yield a total of 8 articles was selected. They show that Exercise programs improving LTM in the elderly involved aerobic activities performed 2-3 times per week. LTM improvements were correlated with brain-specific regions changing volume and depend on intensity, performed at least moderately for a minimum of 2.5 to 3 months. Exercise programs to improve LTM require strict control of exercise intensity, while different training duration and weekly sessions seem effective. Conclusions: Training focusing only in walking sessions requires further investigations to ensure its potential in improving LTM in the elderly.



Physical training; Aging; Learning; Cognition; Memory.

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Cadore EL, Pinto RS, Bottaro M, Izquierdo M. Strength and endurance training prescription in healthy and frail elderly. Aging Dis. 2014;5(3):183-95.

Weerdesteyn V, Rijken H, Geurts AC, Smits-Engelsman BC, Mulder T, Duysens J. A five-week exercise program can reduce falls and improve obstacle avoidance in the elderly. Gerontology. 2006;52(3):131-41.

Izquierdo M, Cadore EL. Muscle power training in the institutionalized frail: a new approach to counteracting functional declines and very late-life disability. Curr Med Res Opin. 2014;30(7):1385-90.

Ko DS, Jung DI, Jeong MA. Analysis of Core Stability Exercise Effect on the Physical and Psychological Function of Elderly Women Vulnerable to Falls during Obstacle Negotiation. Journal of physical therapy science. 2014;26(11):1697-700. Epub 2014/12/02.

Angevaren M, Aufdemkampe G, Verhaar HJ, Aleman A, Vanhees L. Physical activity and enhanced fitness to improve cognitive function in older people without known cognitive impairment. The Cochrane database of systematic reviews. 2008(3):CD005381. Epub 2008/07/23.

Roig M, Nordbrandt S, Geertsen SS, Nielsen JB. The effects of cardiovascular exercise on human memory: a review with meta-analysis. Neuroscience and Biobehavioral Reviews. 2013;37(8):1645-66. Epub 2013/06/29.

Izquierdo I, Barros DM, Mello e Souza T, de Souza MM, Izquierdo LA, Medina JH. Mechanisms for memory types differ. Nature. 1998;393(6686):635-6.

Snigdha S, de Rivera C, Milgram NW, Cotman CW. Exercise enhances memory consolidation in the aging brain. Front Aging Neurosci. 2014;6:3.

McDaniel MA, Binder EF, Bugg JM, Waldum ER, Dufault C, Meyer A, et al. Effects of cognitive training with and without aerobic exercise on cognitively demanding everyday activities. Psychology and aging. 2014;29(3):717-30. Epub 2014/09/23.

Barnes JN. Exercise, cognitive function, and aging. Adv Physiol Educ. 2015;39(2):55-62.

Hogan CL, Mata J, Carstensen LL. Exercise holds immediate benefits for affect and cognition in younger and older adults. Psychology and aging. 2013;28(2):587-94. Epub 2013/06/26.

Nielson KA, Wulff LL, Arentsen TJ. Muscle tension induced after learning enhances long-term narrative and visual memory in healthy older adults. Neurobiology of learning and memory. 2014;109:144-50. Epub 2014/01/18.

Krzeminski K, Cybulski G, Ziemba A, Nazar K. Cardiovascular and hormonal responses to static handgrip in young and older healthy men. European journal of applied physiology. 2012;112(4):1315-25.

Nielson KA, Powless M. Positive and negative sources of emotional arousal enhance long-term word-list retention when induced as long as 30 min after learning. Neurobiology of learning and memory. 2007;88(1):40-7.

Nielson KA, Radtke RC, Jensen RA. Arousal-induced modulation of memory storage processes in humans. Neurobiology of learning and memory. 1996;66(2):133-42.

Nielson KA, Meltzer MA. Modulation of long-term memory by arousal in alexithymia: the role of interpretation. Conscious Cogn. 2009;18(3):786-93.

Hernandez SS, Sandreschi PF, Silva FC, Arancibia BA, da Silva R, Gutierres PJ, et al. What are the Benefits of Exercise for Alzheimer s Disease? A Systematic Review of Past 10 Years. Journal of aging and physical activity. 2014.

Yau SY, Gil-Mohapel J, Christie BR, So KF. Physical exercise-induced adult neurogenesis: a good strategy to prevent cognitive decline in neurodegenerative diseases? BioMed research international. 2014;2014:403120.

Erickson KI, Voss MW, Prakash RS, Basak C, Szabo A, Chaddock L, et al. Exercise training increases size of hippocampus and improves memory. Proceedings of the National Academy of Sciences of the United States of America. 2011;108(7):3017-22. Epub 2011/02/02.

Kamegaya T, Maki Y, Yamagami T, Yamaguchi T, Murai T, Yamaguchi H. Pleasant physical exercise program for prevention of cognitive decline in community-dwelling elderly with subjective memory complaints. Geriatrics & gerontology international. 2012;12(4):673-9. Epub 2012/04/04.

Langlois F, Vu TT, Chasse K, Dupuis G, Kergoat MJ, Bherer L. Benefits of physical exercise training on cognition and quality of life in frail older adults. The journals of gerontology Series B, Psychological sciences and social sciences. 2013;68(3):400-4. Epub 2012/08/30.

Ruscheweyh R, Willemer C, Kruger K, Duning T, Warnecke T, Sommer J, et al. Physical activity and memory functions: an interventional study. Neurobiology of aging. 2011;32(7):1304-19. Epub 2009/09/01.

Tseng BY, Uh J, Rossetti HC, Cullum CM, Diaz-Arrastia RF, Levine BD, et al. Masters athletes exhibit larger regional brain volume and better cognitive performance than sedentary older adults. Journal of magnetic resonance imaging : JMRI. 2013;38(5):1169-76. Epub 2013/08/03.

Theill N, Schumacher V, Adelsberger R, Martin M, Jancke L. Effects of simultaneously performed cognitive and physical training in older adults. BMC neuroscience. 2013;14:103. Epub 2013/09/24.

van Uffelen JG, Chinapaw MJ, Hopman-Rock M, van Mechelen W. Feasibility and effectiveness of a walking program for community-dwelling older adults with mild cognitive impairment. Journal of aging and physical activity. 2009;17(4):398-415. Epub 2009/11/27.

Preston AR, Eichenbaum H. Interplay of hippocampus and prefrontal cortex in memory. Current biology : CB. 2013;23(17):R764-73. Epub 2013/09/14.

Pan W, Banks WA, Fasold MB, Bluth J, Kastin AJ. Transport of brain-derived neurotrophic factor across the blood-brain barrier. Neuropharmacology. 1998;37(12):1553-61.

Erickson KI, Miller DL, Roecklein KA. The aging hippocampus: interactions between exercise, depression, and BDNF. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. 2012;18(1):82-97. Epub 2011/05/03.

Swain RA, Harris AB, Wiener EC, Dutka MV, Morris HD, Theien BE, et al. Prolonged exercise induces angiogenesis and increases cerebral blood volume in primary motor cortex of the rat. Neuroscience. 2003;117(4):1037-46.

Skriver K, Roig M, Lundbye-Jensen J, Pingel J, Helge JW, Kiens B, et al. Acute exercise improves motor memory: exploring potential biomarkers. Neurobiology of learning and memory. 2014;116:46-58. Epub 2014/08/17.


ISSN-L: 2357-9641

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