Epidemiological analysis of nifedipine and phenytoin-induced gingival overgrowth in users of the Primary Health Care System

Authors

  • Luciara Viana Leão Fonseca Universidade Federal dos Vales do Jequitinhonha e Mucuri
  • Hercílio Martelli Júnior Universidade Estadual de Montes Claros
  • Patrícia Furtado Gonçalves Universidade Federal dos Vales do Jequitinhonha e Mucuri
  • Fillipe Mateus Castro de Carvalho Universidade Estadual de Montes Claros
  • Ricardo Della Coletta niversidade Estadual de Campinas
  • Paulo Rogério Ferreti Bonan Universidade Estadual de Montes Claros

Keywords:

Nifedipine, phenytoin, gingival overgrowth, primary health care

Abstract

Purposes: The aim of this study was to evaluate the prevalence of drug-induced gingival overgrowth (DIGO) in Brazilian users of nifedipine and/or phenytoin and to determine the presence of predisposing/modifying factors. Methods: Demographic, pharmacological, and periodontal data were obtained from 100 users of the Brazilian Primary Health Care System in Diamantina, Jequitinhonha Valley, Minas Gerais state, Brazil, who were taking nifedipine and/or phenytoin. Clinical evaluations including gingival overgrowth analysis were carried out by a single calibrated examiner. Bivariate analysis (Chi-square test or Student’s t-test) were used to identify demographic, periodontal and drug-related significant factors associated with gingival overgrowth severity. Multivariate analysis (Poisson regression) was used to assess confounding factors. Results: The prevalence of DIGO was high (86%), but its severity was predominately mild. The prevalence of DIGO was significantly higher in phenytoin users than in nifedipine users (p=0.01). There was no association between DIGO and demographic, pharmacological or periodontal variables. Conclusion: The high occurrence of DIGO among users of nifedipine and phenytoin emphasizes the importance of the dentist as part of the public health team to provide the prevention, early diagnostic, and control of this alteration.

Author Biographies

Luciara Viana Leão Fonseca, Universidade Federal dos Vales do Jequitinhonha e Mucuri

Professora Assistente da Disciplina de Odontologia em Saúde Coletiva da Universidade Federal dos Vales do Jequitinhonha e Mucuri, Mestrado em Cuidado Primário em Saúde pela Universidade Estadual de Montes Claros e Doutoranda em Saúde Da criança e do adolescente, pela Universidade Federal de Minas Gerais

Hercílio Martelli Júnior, Universidade Estadual de Montes Claros

Doutorado em Estomatopatologia pela Universidade Estadual de Campinas, Brasil(2002) Responsável pela Disciplina de Estomatologia da Universidade Estadual de Montes Claros , Brasil

Patrícia Furtado Gonçalves, Universidade Federal dos Vales do Jequitinhonha e Mucuri

Doutorado em Clínica Odontológica pela Universidade Estadual de Campinas, Brasil(2006) Professora Adjunta da Universidade Federal dos Vales do Jequitinhonha e Mucuri , Brasil

Fillipe Mateus Castro de Carvalho, Universidade Estadual de Montes Claros

graduando do curso de Odontologia

Ricardo Della Coletta, niversidade Estadual de Campinas

Doutorado em Biologia Patologia Buco Dental pela Universidade Estadual de Campinas, Brasil(1999) Professor Associado referencia MS-5 da Universidade Estadual de Campinas , Brasil

Paulo Rogério Ferreti Bonan, Universidade Estadual de Montes Claros

Doutorado em Estomatopatologia pela Universidade Estadual de Campinas, Brasil(2004) Professor da Universidade Estadual de Montes Claros , Brasil

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Published

2010-04-09

Issue

Vol. 25 No. 2 (2010)

Section

Original Article

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