Evaluation of the effectiveness of Matricaria recutita Linn. in the prevention and control of radiation-induced oral mucositis

Tatiana Stuart Vieira Holmes, Jozinete Vieira Pereira, Daliana Queiroga de Castro Gomes, Maria do Socorro Vieira Pereira, Danúbia Roberta de Medeiros Nóbrega, Manuela Gouvêa Campêlo dos Santos

Abstract


Objective: To investigate the effectiveness of Matricaria recutita Linn. (chamomile) in the prevention and control of radiation-induced oral mucositis.
Methods: The sample consisted of 22 patients who were divided into three groups: group I (experimental) (n=7), patients were treated with 3% chamomile gel throughout the radiotherapy
course; group II (positive control) (n=7), the treatment was carried out using 1% chlorhexidine gluconate gel only at the onset of mucositis until regression of symptoms; and group III (experimental) (n=8), patients with mucositis were treated with 3% chamomile gel following the same protocol described for group II.
Results: The results showed there were no statistically significant differences between the three groups (P>0.05). However, descriptive data indicated that group II was found to show the fastest clinical improvement in oral treatment, whereas group III took the longest period to show clinical improvement of mucositis.
Conclusion: Chamomile had no prophylactic effect on the onset of oral mucositis, but it was proven to be effective in decreasing the severity of this condition during treatment in most patients.

Keywords


Head and neck neoplasms; radiotherapy; mucositis; phytotherapy; chamomile;

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References


Scully C, Porter S. Oral cancer. West J Med 2001;174(5):348-51.

Bonan PRF, Pires FR, Lopes MA, Hipólito JO. Evaluation of salivary flow in patients during head and neck radiotherapy. Pesqui Odontol Bras 2003;17(2):156-60.

Tolentino ES, Centurion BS, Ferreira LHC, Souza AP, Damante JH, Rubira-Bullen IRF. Oral adverse effects of head and neck radiotherapy: literature review and suggestion of a clinical oral care guideline for irradiated patients. J Appl Oral Sci 2011;19(5):448-54.

Andrews N, Griffiths C. Dental complications of head and neck

radiotherapy. J Austr Dent 2001;46:88-4.

Köstler W J, Hejna M, Wenzel C, Zielinski CC. Oral mucositis complicating chemotherapy and/or radiotherapy: options for prevention and treatment. CA Cancer J Clin 2001;51:290-15.

Roopashri G, Jayanthi K, Guruprasad R. Efficacy of benzydamine

hydrochloride, chlorhexidine, and povidone iodine in the treatment of oral mucositis among patients undergoing radiotherapy in head and neck malignancies: A drug trail. Contemp Clin Dent 2011;2(1):8-12.

Dörr W, Hamilton CS, Boyd T, Reed B, Denham JW. Radiation-induced changes in cellularity and proliferation in human oral mucosa. Int J Radiat Oncol Biol Phys 2001;52(4):911-7.

Sutherland, SE, Browman, GP. Prophylaxis of oral mucositis in irradiated head and neck cancer patients: a proposed classification scheme of interventions and meta – analysis of randomized controlled trials. Int J Radiat Oncol Biol Phys 2001; 49(4):917-30.

Volpato LER, Silva TC, Oliveira TM, Sakai VT, Machado MAAM.

Radiation therapy and chemotherapy-induced oral mucositis. Rev Bras Otorrinolaringol 2007; 73(4):562-8.

Mckay DL, Blumberg JB. A review of the bioactivity and potential health benefits of Chamomile Tea (Matricaria recutita L.). Phytother Res 2006; (20):519-30.

World Medical Association Declaration of Helsinki. Adopted by the 18th WMA General Assembly, Helsinki, Finland (1964)[online] [Acessed: Aug. 2012].

Karnofsky DA, Burchenal JH, Armistead GC, Craver LF. Trienthylinemelamine in the treatment of neoplastic disease. Arch Intern Med 1951; 87:477-16.

Lockhart PT, Clark, J. Pretherapy dental status of pacients with malignant conditions of the head and neck.Oral Surg Oral Med Oral Pathol 1994;77(3):236-41.

Miller A B,Hoogstrate MB, Staquet M, Winkler A. Reporting results of cancer. Cancer 1981;47:207-14.

Lima AG, Antequera R, Peres MPSM, Snitcosky IML,Federico MHH, Villar RC. Efficacy of Low-Level Laser Therapy and Aluminum Hydroxide in Patients with Chemotherapy and Radiotherapy-Induced Oral Mucositis. Braz Dent J 2010;21(3):186-92.

Weijers M, Leemans CR, Aartman IH, Karagozoglu KH, Isaäc van-der-Waal I. Oral cancer trends in a single head-and-neck cancer center in the Netherlands; decline in T-stage at the time of admission. Med Oral Patol Oral Cir Bucal 2011;16(7):914-8.

Suresh AVS, Varma PP, Sinha S, Deepika S, Raman R, Srinivasan M et al. Risk-scoring system for predicting mucositis in patients of head and neck cancer receiving concurrent Chemoradiotherapy. J Cancer Res Ther 2010;6(4):448-51.

Durazzo MD, Araujo CEN, Brandão Neto JS, Potenza AS, Costa P, Takeda F et al. Clinical and epidemiological features of oral cancer in a medical school teaching hospital from 1994 to 2002: increasing incidence in women, predominance of advanced local disease, and low incidence of neck metastases. Clinics 2005;60(4):293-8.

Epstein JB, Klasser GD. Emerging approaches for prophylaxis in cancer management of oropharyngeal mucositis in cancer therapy. Expert Opin Emerg Drugs 2006;11(2):353-73.

Handschel J, Sunderköter C, Prott FJ, Meyer U, Kruse-Lösler B, Joos U. Increase of RM 3/1 – positive macrophages in radiation induced oral mucositis. J Pathol 2001;193(2):242-7.

Sonis ST. A biological approach to mucositis. J Support Oncol 2004; 2(1):21-6.

Lanzós I, Herrera D, Santos S, O’Connor A, Peña C, Lanzós E et al.

Mucositis in irradiated câncer patients: Effects of an antiseptic mouthrinse. Med Oral Patol Oral Cir Bucal 2010;15(5):732-78.

Soares AF, Aquino ARL, Carvalho CHP, Nonaka CFW, Almeida D, Pereira Pinto L. Frequency of Oral Mucositis and Microbiological Analysis in Children with Acute Lymphoblastic Leukemia Treated with 0.12% Chlorhexidine Gluconate. Braz Dent J 2011;22(4):312-6.

Mazokopakis EE, Vrentzos GE, Papadakis JA, Babalis DE, Ganotakis ES. Wild chamomile (Matricaria recutita L.) mouthwashes in methotrexateinduced oral mucosits. Phytomedicine 2005;12(1):25-7.

Pavesi VCS. et al. Healing action of topical chamomile on 5-fluouracil induced oral mucositis in hamster. Support Care Cancer 2011;19: 639-46.

Oehler C, Bensdorf K, Gust R, Imming P. Chamavioline – Antiedematous, but not a constituent of Matricaria recutita L. Phytochem Lett 2009;2(4): 171-5.




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