Evaluation of the effectiveness of Matricaria recutita Linn. in the prevention and control of radiation-induced oral mucositis

Tatiana Stuart Vieira Holmes, Jozinete Vieira Pereira, Daliana Queiroga de Castro Gomes, Maria do Socorro Vieira Pereira, Danúbia Roberta de Medeiros Nóbrega, Manuela Gouvêa Campêlo dos Santos


Objective: To investigate the effectiveness of Matricaria recutita Linn. (chamomile) in the prevention and control of radiation-induced oral mucositis.
Methods: The sample consisted of 22 patients who were divided into three groups: group I (experimental) (n=7), patients were treated with 3% chamomile gel throughout the radiotherapy
course; group II (positive control) (n=7), the treatment was carried out using 1% chlorhexidine gluconate gel only at the onset of mucositis until regression of symptoms; and group III (experimental) (n=8), patients with mucositis were treated with 3% chamomile gel following the same protocol described for group II.
Results: The results showed there were no statistically significant differences between the three groups (P>0.05). However, descriptive data indicated that group II was found to show the fastest clinical improvement in oral treatment, whereas group III took the longest period to show clinical improvement of mucositis.
Conclusion: Chamomile had no prophylactic effect on the onset of oral mucositis, but it was proven to be effective in decreasing the severity of this condition during treatment in most patients.


Head and neck neoplasms; radiotherapy; mucositis; phytotherapy; chamomile;

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