Efecto de colutorio-gel de clorhexidina sobre el crecimiento de placa en 24 horas
Abstract
En un estudio cruzado, doble ciego y randomizado, 25 alumnos de Odontologia de buena salud oral, participaron de cuatro estudios donde ellos se abtuvieron de toda limpieza mecanica oral por 24 horas, los estudios estuvieron separados entre si por 4 semanas. Durante los estudios los alumnos en un randomizado orden, se enjuagaron por una vez con uno de los siguientes colutorios: CHX 0.12% + alcohol (Oralgene®), CHX 0.12% + alcohol (Perio.Aid®), CHX 0.1% + alcohol (Dentilim®) y CHX 0.1% + HMC 2.5% (Colutoriogel®, nueva formula). Despues de un dia se midio formación de placa, se completo y registro el cuestionario de parametros clinicos. Las formulaciones de CHX 0.12% + alcohol y CHX 0.1% + HMC 2.5% se mostraron eficientes en retardar el crecimiento de placa dental de novo, esto obtenido de las observaciones clinicas, y siempre superior (p < 0.05) a la formulación del colutorio de CHX 0.1%+ alcohol (Dentilim®). Los resultados de este estudio demuestran el potencial clinico de este nuevo colutorio-gel sin alcohol de CHX 0.1% + HMC 2.5% (Colutoriogel®) como un efectivo agente antiplaca y con reducidas efectos secundarios registrados.
UNITERMOS: clorhexidina; colutorio-gel; indice placa; colutorios.
SUMMARY
In double-blind, randomised, cross-over study, 25 young dental students with a healthy periodontium, abolished all means of mechanical plaque control during 4 experimental periods of 1 days (separated from each other by a washout period of 4 weeks). During each experimental period, they rinsed 1× daily with one of the following mouthrinses in a randomised order: CHX 0.12% + alcohol (Oralgene®), CHX 0.12% + alcohol (Perio.Aid®), CHX 0.1% + alcohol (Dentilim®) and CHX 0.1% + HMC 2.5% (Colutoriogel®, new formulation). After 1 days of undisturbed plaque formation, clinical parameters were recorded and questionnaires completed. The CHX 0.12% + alcohol and the and CHX 0.1% + HMC 2.5% formulations were efficient in retarding de novo plaque formation (proven by clinical observations data), and always superior (p < 0.05) to the CHX 0.1%+ alcohol (Dentilim®) solution. The results of this study demonstrated the potential of a new CHX 0.1% + HMC 2.5% (Colutoriogel®) non-alcoholic formulation as an effective anti-plaque agent with reduced unpleasant subjective side-effects.
UNITERMS: clorhexidine; mouthrinses-gel; plaque index; mouthrinses.
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