%PDF-1.3 % 2 0 obj << /Length 6614 >> stream /Cs6 CS 0 0 0 SCN 0 J 0 j 0.48 w 10 M []0 d /GS1 gs 1 i 48.02 75.04 m 546.98 75.04 l S BT /TT1 1 Tf 10 0 0 10 48.02 64 Tm /Cs6 cs 0 0 0 scn 0.0107 Tc 0 Tw (354)Tj /TT2 1 Tf 8 0 0 8 66.62 64 Tm 0.0396 Tc [( )26.5( )]TJ /TT3 1 Tf 1.635 0 TD 0.0158 Tc 0.025 Tw (Revista Odonto Cincia )Tj /TT2 1 Tf 11.22 0 TD 0.0149 Tc 0.0271 Tw [( Fac. Odonto/PUCRS, v)74.9(.)0.6( 20, n. 50, out./dez. 2005)]TJ /TT3 1 Tf -15.18 92.34 TD 0.0139 Tc 0.0375 Tw (Efeito da dexametasona e do meloxicam sobre ...)Tj /TT2 1 Tf 42.57 0 TD 0.0154 Tc 0.0279 Tw [(Boleta-Ceranto DCF)120.4(, V)60.4(eiga MCF)45.4(A, Arsati F)]TJ ET 1 1 1 scn 48.05 811.85 498.9 -14.15 re f* 1.92 w 274.7 809.8 m 320.3 809.8 l S 0.36 w 274.7 806.98 m 320.3 806.98 l S BT /TT4 1 Tf 16 0 0 16 274.94 790.6 Tm 0 0 0 scn 0 Tc 0 Tw (A)Tj -0.03 0 TD (A)Tj 0.03 0.03 TD (A)Tj -0.03 0 TD (A)Tj 0.015 -0.015 TD (A)Tj 12.8 0 0 12.8 284.612 790.648 Tm (R)Tj -0.03 0 TD (R)Tj 0.03 0.03 TD (R)Tj -0.03 0 TD (R)Tj 0.015 -0.015 TD (R)Tj 0.5869 -0.015 TD -0.0001 Tc (TIGO)Tj -0.03 0 TD (TIGO)Tj 0.03 0.03 TD (TIGO)Tj -0.03 0 TD (TIGO)Tj 0.015 -0.015 TD (TIGO)Tj /TT5 1 Tf 24.2 0 0 22 112.46 740.92 Tm 0.0017 Tc -0.0206 Tw [(EFEITO DA DEXAMET)41.4(ASONA E DO MELOXICAM SOBRE)]TJ -1.5917 -1.0909 TD -0.0289 Tw [(O EXTRA)31.6(V)23.8(ASAMENTO PLASMTICO INDUZIDO POR CARRAGENINA)]TJ 6.6298 -1.0909 TD -0.0126 Tw [(NA A)31.6(TM DE RA)41.5(TOS)]TJ /TT6 1 Tf 15.4 0 0 14 99.26 666.4 Tm 0.0145 Tc 0.0005 Tw [(EFFECT OF DEXAMETHASONE AND MELOXICAM ON PLASMA EXTRA)30.1(V)29.4(ASA)37.9(TION INDUCED)]TJ 4.1844 -1.0714 TD 0.0146 Tc -0.0032 Tw [(BY CARRAGEENAN INTO RA)45.8(T TEMPOROMANDIBULAR JOINT)]TJ ET 0.24 w 218.18 637.72 m 376.82 637.72 l S BT /TT7 1 Tf 12.1 0 0 11 173.06 609.52 Tm 0.0221 Tc -0.0283 Tw [(Boleta-Ceranto)32(, Daniela de Cassia F)32(aglioni*)]TJ 1.1008 -1.0909 TD 0.0225 Tc -0.0278 Tw [(V)43.1(eiga)12.6(, Maria Ceclia F)22.5(erraz de Arruda**)]TJ ET 0.48 w 90.5 567.64 m 504.5 567.64 l S 1.68 w 90.5 565.36 m 504.5 565.36 l S 0.48 w 90.5 563.08 m 504.5 563.08 l S BT 12.1 0 0 11 250.34 585.52 Tm 0.0218 Tc -0.0299 Tw [(Arsati)11.9(, F)21.8(ranco***)]TJ /TT8 1 Tf 9 0 0 9 276.5 523.48 Tm 0.0123 Tc 0 Tw (RESUMO)Tj /TT1 1 Tf -18.7733 -2.08 TD 0.0145 Tc 0.0038 Tw [(A dor orofacial comumente ocorre devido inflamao aguda ou crnica. P)41.2(orm, pouco se)]TJ -1.8933 -1.2133 TD -0.0343 Tw [(sabe sobre os mecanismos fisiopatolgicos envolvidos na inflamao e na dor inflamatria pre)-52.2(-)]TJ 0 -1.2267 TD 0.0147 Tc -0.0288 Tw (sentes nas disfunes temporomandibulares. Nosso objetivo foi desenvolver um modelo para o)Tj T* 0.0074 Tw [(estudo da inflamao aguda na regio da articulao temporomandibular \(A)54.7(TM\) de ratos utili-)]TJ 0 -1.2133 TD 0.0145 Tc -0.0264 Tw [(zando carragenina \(CA\) e verificar os possveis efeitos de drogas antiinflamatrias nesse mode)-52.2(-)]TJ 0 -1.2267 TD 0.1277 Tw (lo. A inflamao foi avaliada atravs do extravasamento plasmtico \(EP\) do corante azul de)Tj T* 0.0146 Tc -0.0545 Tw [(Evans, por espectrofotometria comparada A)54.6(TM contralateral que serviu como controle e rece)-38.7(-)]TJ 0 -1.2133 TD 0.0693 Tw (beu injeo de salina. Um experimento com relao ao tempo do efeito da CA sobre o EP do)Tj 0 -1.2267 TD 0.0148 Tc 0.0641 Tw (corante Azul de Evans revelou um efeito mximo no tempo de 60 min aps a administrao.)Tj T* 0.0199 Tc 0.1527 Tw (O experimento dose resposta demonstrou que a administrao de CA a partir da dose de)Tj 0 -1.2133 TD 0.0149 Tc 0.0196 Tw [(300 g/50 L, causava um EP estatisticamente significante em relao ao controle. A adminis)-25.1(-)]TJ 0 -1.2267 TD 0.0144 Tc 0 Tw [(trao de drogas antiinflamatrias \(dexametasona e meloxicam\) somente foram capazes de re)-52.3(-)]TJ T* 0.0148 Tc 0.0884 Tw (duzir a inflamao em altas doses. 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Our objective was to develop an orofacial)Tj T* 0.1111 Tw (model of acute inflammation in rats, using carrageenan and verify the possible effects of)Tj 0 -1.2133 TD 0.0201 Tc 0.1838 Tw (antiinflamatory drugs in this model. The inflammation was evalued by protein plasma)Tj 0 -1.2267 TD 0.0138 Tc -0.0022 Tw (extravasation of blue Evans dye through spectrophotometry compared to contralateral TMJ)Tj T* 0.014 Tc 0.0063 Tw (that was the control. An experiment related to the time of the carrageenan effect on plasma)Tj 0 -1.2133 TD 0.0142 Tc 0.1517 Tw (extravasation of blue Evans dye showed a maximal effect at 60 min after carrageenan)Tj 0 -1.2267 TD 0.0131 Tc -0.061 Tw [(administration. The dose)-40.2(-response experiment showed that from a dose of 300 g/50 l, there)]TJ T* 0.003 Tc (was a plasma extravasation statiscally significant compared to the control. The administration)Tj 0 -1.2133 TD 0.0201 Tc 0.1919 Tw (of antiinflamatory drugs \(dexamethasone and meloxican\) only were able to reduce the)Tj 0 -1.2267 TD 0.0059 Tc -0.0611 Tw (inflammation in high doses. In conclusion: 1\) the intra-articular administration of carrageenan)Tj ET 48.02 138.04 m 93.38 138.04 l S BT /TT1 1 Tf 8 0 0 8 58.1 128.32 Tm 0.0103 Tc -0.0613 Tw [(*)-359.7(Mestre e Doutora em Odontologia, rea de concentrao em F)25.3(isiologia Oral. P)25.3(rofessora da Universidade P)40.3(aranaense UNIP)70.3(AR.)]TJ -0.525 -1.125 TD 0.0167 Tc 0.0033 Tw [(*)-33.3(*)-328.3(Mestre em Cincias Biolgicas e Doutora em Odontologia. P)16.7(rofessora da F)91.7(aculdade de Odontologia de Piracicaba, Universi-)]TJ 1.395 -1.125 TD 0.0156 Tc 0.0125 Tw [(dade Estadual de Campinas FOP/UNICAMP)255.6(.)]TJ -1.92 -1.125 TD 0.013 Tc -0.0612 Tw [(*)-24.5(*)-24.5(*)-332(Mestre e Doutor em Odontologia, rea de concentrao em F)13(isiologia Oral. P)13(rofessor da Universidade Metodista de Piracicaba)]TJ 1.92 -1.125 TD 0.0168 Tc 0.0062 Tw [( UNIMEP)256.8(.)]TJ ET endstream endobj 3 0 obj << /ProcSet [/PDF /Text ] /Font << /TT1 4 0 R /TT2 5 0 R /TT3 6 0 R /TT4 7 0 R /TT5 8 0 R /TT6 9 0 R /TT7 10 0 R /TT8 11 0 R /TT9 12 0 R /TT10 13 0 R >> /ExtGState << /GS1 14 0 R >> /ColorSpace << /Cs6 15 0 R >> >> endobj 15 0 obj [/ICCBased 17 0 R] endobj 17 0 obj << /N 3 /Alternate /DeviceRGB /Length 2572 /Filter /FlateDecode >> stream HyTSwoɞc [5laQIBHADED2mtFOE.c}088GNg9w߽ '0 ֠Jb 2y.-;!KZ ^i"L0- @8(r;q7Ly&Qq4j|9 V)gB0iW8#8wթ8_٥ʨQQj@&A)/g>'K t;\ ӥ$պFZUn(4T%)뫔0C&Zi8bxEB;Pӓ̹Aom?W= x- [ 0}y)7ta>jT7@tܛ`q2ʀ&6ZLĄ?_yxg)˔zçLU*uSkSeO4?c. 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Odonto/PUCRS, v. 20, n. 50, out./dez. 2005 )]TJ /TT1 1 Tf 10 0 0 10 528.38 64 Tm 0.0167 Tc 0 Tw (355)Tj /TT3 1 Tf 8 0 0 8 48.02 802.72 Tm 0.0139 Tc 0.0375 Tw (Efeito da dexametasona e do meloxicam sobre ...)Tj /TT2 1 Tf 42.57 0 TD 0.0154 Tc 0.0279 Tw [(Boleta-Ceranto DCF)120.4(, V)60.4(eiga MCF)45.4(A, Arsati F)]TJ /TT8 1 Tf 11 0 0 11 48.02 671.6801 Tm 0.0112 Tc 0 Tw (INTRODUO)Tj /TT1 1 Tf 10 0 0 10 65.06 651.64 Tm 0.0118 Tc -0.0399 Tw [(Estima-)-36.2(se que cerca de 20% a 30% da popula-)]TJ -1.704 -1.284 TD 0.0177 Tc 0.379 Tw (o apresentar algum sintoma de disfuno)Tj 0 -1.296 TD 0.0173 Tc 0.4912 Tw (temporomandibular \(DTM\) durante sua vida)Tj 0 -1.284 TD 0.0113 Tc -0.03 Tw (\(Alder et al.)Tj 6 0 0 6 103.94 616 Tm 0 Tc 0 Tw (1)Tj 10 0 0 10 107.66 613 Tm 0.0114 Tc -0.03 Tw (, 1992\). A dor associada DTM pode)Tj -5.964 -1.296 TD 0.0087 Tc -0.0608 Tw [(ocorrer em at 70% dos pacientes portadores des)-27.3(-)]TJ 0 -1.284 TD 0.0033 Tc -0.0613 Tw (tas disfunes \(Swift et al.)Tj 6 0 0 6 170.3 590.2 Tm 0.0022 Tc 0 Tw (24)Tj 10 0 0 10 177.62 587.2 Tm 0 Tc (,)Tj /TT10 1 Tf 0.312 0 TD ( )Tj /TT1 1 Tf 0.252 0 TD 0.0028 Tc -0.0616 Tw (1998\). A dor orofacial)Tj -13.524 -1.296 TD 0.0118 Tc -0.0375 Tw (ocorre mais comumente devido inflamao agu-)Tj 0 -1.284 TD -0.05 Tw (da ou crnica e muito freqentemente refratria)Tj 0 -1.296 TD -0.055 Tw [(aos protocolos de tratamento existentes. P)23.9(ara que)]TJ 0 -1.284 TD 0.0061 Tc -0.0608 Tw [(ocorram avanos no tratamento das dores relacio)-41.9(-)]TJ 0 -1.296 TD 0.0176 Tc 0.1774 Tw [(nadas s DTMs, faz-)-42.4(se necessria uma melhor)]TJ T* 0.0001 Tc -0.061 Tw [(compreenso dos mecanismos envolvidos nos pro)-35.9(-)]TJ 0 -1.308 TD 0.012 Tc 0.009 Tw (cessos inflamatrios que acometem a articulao)Tj 0 -1.296 TD 0.0114 Tc 0.11 Tw [(temporomandibular \(A)47.4(TM\) \(Hass et al.)]TJ 6 0 0 6 239.78 486.64 Tm 0.0022 Tc 0 Tw (12)Tj 10 0 0 10 247.22 483.64 Tm 0.0118 Tc 0.11 Tw (, 1992\).)Tj -19.92 -1.296 TD 0.011 Tw (Infelizmente, contudo, h poucos estudos espec-)Tj 0 -1.308 TD -0.0336 Tw (ficos sobre inflamao em tecidos orais ou faciais)Tj 0 -1.296 TD 0.012 Tc -0.05 Tw [(\()9(F)84(azekas et al.)]TJ 6 0 0 6 115.7 447.64 Tm 0 Tc 0 Tw (7)Tj 10 0 0 10 119.42 444.64 Tm (,)Tj /TT10 1 Tf 0.312 0 TD ( )Tj /TT1 1 Tf 0.276 0 TD 0.0117 Tc -0.0517 Tw (1990; Okiji et al.)Tj 6 0 0 6 205.58 447.64 Tm 0.0022 Tc 0 Tw (20)Tj 10 0 0 10 213.02 444.64 Tm 0.0113 Tc -0.0525 Tw [(, 1991\). Conse)-36.7(-)]TJ -16.5 -1.296 TD 0.0119 Tc 0.0634 Tw [(qentemente, pouco se sabe sobre o\(s\) mecanis)-24.1(-)]TJ 0 -1.308 TD 0.0116 Tc 0.0393 Tw (mo\(s\) envolvido\(s\) tanto no incio quanto na ma-)Tj 0 -1.296 TD 0.0107 Tc -0.0607 Tw (nuteno da inflamao aguda e da dor inflamat-)Tj T* 0.0116 Tc -0.0483 Tw [(ria na regio da A)47.6(TM. Modelos de processos infla-)]TJ 0 -1.308 TD 0.0584 Tw (matrios na regio orofacial so restritos devido)Tj 0 -1.296 TD -0.0082 Tc -0.0348 Tw [(s dificuldades em )]TJ 8.9088 0 TD 0.0116 Tc -0.035 Tw (medir os fatores inflamatrios.)Tj -8.9088 -1.296 TD 0.105 Tw (Dessa forma, modelos de inflamao provenien-)Tj 0 -1.308 TD -0.0275 Tw (tes de outras regies do organismo tm sido utili-)Tj 0 -1.296 TD 0.0119 Tc -0.0609 Tw (zados, mesmo por aqueles com interesse especfi-)Tj T* 0.0031 Tc (co nos mecanismos relacionados regio orofacial)Tj 0 -1.308 TD 0.0111 Tc 0.0375 Tw (\(Hargreaves et al.)Tj 6 0 0 6 132.98 304.6 Tm 0.0022 Tc 0 Tw (11)Tj 10 0 0 10 140.42 301.6 Tm 0.012 Tc 0.04 Tw (, 1989; Hylden et al.)Tj 6 0 0 6 240.5 304.6 Tm 0.0022 Tc 0 Tw (15)Tj 10 0 0 10 247.94 301.6 Tm 0.0115 Tc 0.04 Tw (, 1991\).)Tj -19.992 -1.296 TD -0.025 Tw [(Um modelo orofacial ideal para estudo da dor re)-36.4(-)]TJ T* 0.0117 Tc 0.0075 Tw (lacionada a processos inflamatrios deveria ter a)Tj 0 -1.308 TD 0.0118 Tc 0.0164 Tw (vantagem de permitir o estudo da inflamao em)Tj 0 -1.296 TD 0.0121 Tc 0.0543 Tw [(mbito geral, bem como os mecanismos que po)-35.9(-)]TJ T* 0.0118 Tc 0.0384 Tw [(deriam ser especficos aos tecidos orofaciais, as)-24.2(-)]TJ 0 -1.308 TD 0.0178 Tc 0.1825 Tw (sim como algumas formas de DTMs, infeces)Tj 0 -1.296 TD 0.0119 Tc 0.096 Tw [(dentrias e inflamaes ps)-12.1(-)-43(cirrgicas. P)47.9(or essa)]TJ T* 0.0175 Tc 0.1533 Tw (razo, Hass et al.)Tj 6 0 0 6 137.18 200.68 Tm 0.0222 Tc 0 Tw (12)Tj 10 0 0 10 144.62 197.68 Tm 0.0175 Tc 0.1533 Tw (, \(1992\), desenvolveram um)Tj -9.66 -1.308 TD 0.0117 Tc 0.0283 Tw (modelo de inflamao aguda em tecido profundo)Tj 0 -1.296 TD 0.0175 Tc 0.2115 Tw [(\()9.7(A)41.5(TM\) da regio orofacial de ratos, atravs da)]TJ T* 0.0118 Tc -0.015 Tw (quantificao do extravasamento plasmtico \(EP\))Tj 0 -1.308 TD 0.0116 Tc 0.0899 Tw (induzido pela injeo de leo de mostarda \(OM\))Tj 0 -1.296 TD -0.0031 Tc -0.0612 Tw [(na regio articular)104.9(. Alm do OM vrias outras subs)-15.1(-)]TJ T* 0.0117 Tc 0.0436 Tw (tncias so utilizadas para estudo e avaliao de)Tj 0 -1.308 TD 0.0145 Tc 0.1527 Tw [(drogas antiinflamatrias \(Wheeler)38.5(-)19.6(Aceto et al.)]TJ 6 0 0 6 275.66 109.6 Tm 0.0222 Tc 0 Tw (27)Tj 10 0 0 10 283.1 106.6 Tm 0 Tc (,)Tj -23.508 -1.296 TD 0.0141 Tc 0.1519 Tw [(1990\). Em 1962, W)26.1(inter et al.)]TJ 6 0 0 6 200.9 96.64 Tm 0.0022 Tc 0 Tw (28)Tj 10 0 0 10 208.34 93.64 Tm 0.0147 Tc 0.155 Tw (, aps testarem)Tj 10.056 57.804 TD 0.0132 Tc 0.1525 Tw (uma variedade de materiais capazes de induzir)Tj 0 -1.296 TD 0.018 Tc 0.23 Tw (inflamao, concluram que o agente flogstico)Tj 0 -1.308 TD 0.0178 Tc 0.2517 Tw (de escolha para testar antiinflamatrios era a)Tj 0 -1.296 TD 0.0089 Tc -0.0613 Tw (Carragenina \(CA\), um mucopolissacardeo deriva-)Tj T* 0.0175 Tc 0.192 Tw (do de algas marinhas denominadas )Tj /TT10 1 Tf 18.66 0 TD 0.0187 Tc 0 Tw (Chondrus.)Tj /TT1 1 Tf -18.66 -1.308 TD 0.0117 Tc 0.0264 Tw (Diferentemente do OM, a CA causa uma inflama-)Tj 0 -1.296 TD 0.0113 Tc -0.06 Tw [(o do tipo no)-36.7(-neurognica \(Louis et al.)]TJ 6 0 0 6 502.34 596.68 Tm 0.0022 Tc 0 Tw (18)Tj 10 0 0 10 509.9 593.68 Tm 0.0111 Tc -0.065 Tw (, 1989\),)Tj -20.1 -1.296 TD 0.0119 Tc 0.0286 Tw (no antignica, no produz efeitos sistmicos e)Tj 0 -1.308 TD 0.0175 Tc 0.313 Tw (proporciona um alto grau de reprodutividade)Tj 0 -1.296 TD -0.0033 Tc -0.0597 Tw [(\(W)44.7(inter et al.)]TJ 6 0 0 6 367.7 557.68 Tm -0.0178 Tc 0 Tw (28)Tj 10 0 0 10 374.9 554.68 Tm -0.0037 Tc -0.0608 Tw [( 1962\). Sendo assim, o objetivo deste)]TJ -6.6 -1.296 TD 0.0116 Tc 0.0385 Tw (trabalho foi padronizar um modelo de estudo de)Tj 0 -1.308 TD 0.0405 Tw [(processos inflamatrios na regio da A)71.5(TM de ra-)]TJ 0 -1.296 TD 0.012 Tc -0.0527 Tw [(tos utilizando a CA)-12(, bem como testar os efeitos da)]TJ T* 0.0116 Tc 0.047 Tw (injeo intra-peritoneal \(i.p.\) de drogas antiinfla-)Tj 0 -1.308 TD 0.0192 Tw [(matrias sobre o EP induzido. Utilizou-)-24.3(se para o)]TJ 0 -1.296 TD 0.03 Tw (estudo ratos anestesiados. O sinal de inflamao)Tj T* 0.0069 Tc -0.0612 Tw (selecionado como medida foi o EP do corante Azul)Tj 0 -1.308 TD 0.0111 Tc -0.015 Tw (de Evans \(AE\).)Tj /TT8 1 Tf 11 0 0 11 308.9 419.2 Tm 0.01 Tc 0.0046 Tw [(MA)64.5(TERIAL E MTODOS)]TJ 0 -1.9964 TD (Induo da inflamao)Tj /TT1 1 Tf 10 0 0 10 325.82 378.76 Tm 0.0116 Tc 0.0206 Tw [(F)93.4(oram utilizados ratos W)23.6(istar de 02 a 03 me)-36.4(-)]TJ -1.692 -1.308 TD 0.0134 Tc 0.153 Tw (ses, provenientes do Centro Multidisciplinar de)Tj 0 -1.296 TD 0.0113 Tc 0.043 Tw [(Bioterismo \(CEMIB\) da UNICAMP)]TJ 16.248 0 TD 0.0116 Tc (, pesando entre)Tj -16.248 -1.296 TD 0.0119 Tc 0.0599 Tw [(270-370 g)47.9(.)0.2( Os animais foram mantidos em gaio)-36.1(-)]TJ 0 -1.308 TD 0.1469 Tw (las plsticas, em nmero de 05 por gaiola, sob)Tj 0 -1.296 TD 0.016 Tw (condies constantes de temperatura, umidade e)Tj 0 -1.284 TD 0.0287 Tw [(ciclos de claro/escuro de 12h, com livre acesso )]TJ 0 -1.296 TD 0.0114 Tc -0.0134 Tw (comida e gua \(Rosland)Tj 6 0 0 6 423.98 290.92 Tm 0.0022 Tc 0 Tw (23)Tj 10 0 0 10 431.42 287.92 Tm 0.0114 Tc -0.015 Tw (, 1991\). Os animais no)Tj -12.252 -1.284 TD 0.0141 Tc 0.153 Tw (foram manuseados antes dos experimentos. Os)Tj 0 -1.296 TD 0 Tc -0.0608 Tw [(procedimentos foram realizados no perodo da tar)48(-)]TJ 0 -1.284 TD 0.0023 Tc -0.06 Tw (de entre 13h e 17h \(Labrecque et al.)Tj 6 0 0 6 477.14 252.28 Tm 0.0022 Tc 0 Tw (17)Tj 10 0 0 10 484.46 249.28 Tm 0.0021 Tc -0.0625 Tw (, 1984\). Aps)Tj -17.556 -1.296 TD 0.0104 Tc -0.0607 Tw (serem avaliados e aprovados pelo Comit de tica)Tj 0 -1.284 TD 0.0121 Tc -0.0309 Tw [(em Experimentao Animal do Instituto de Biolo)-23.9(-)]TJ 0 -1.296 TD 0.0114 Tc -0.0362 Tw [(gia \(CEEA\)-IB)-12.6(-UNICAMP)251.4(, protocolo n 135-1.)]TJ 1.692 -1.296 TD 0.0118 Tc 0.027 Tw [(T)84.9(odos os experimentos foram realizados com)]TJ -1.692 -1.296 TD 0.015 Tw [(os animais sob anestesia geral induzida por inje)-24.2(-)]TJ T* 0.0162 Tc 0.1525 Tw (o intraperitoneal de uma mistura de uretano)Tj 0 -1.308 TD 0.0114 Tc 0.0775 Tw [(\(urethane)-24.6(-)-43.5(ethyl-)-36.6(carbamate Sigma)]TJ 6 0 0 6 480.14 161.56 Tm 0 Tc 0 Tw ()Tj 10 0 0 10 485.3 158.56 Tm 0.0123 Tc 0.08 Tw [( U2500\), so)-23.7(-)]TJ -17.64 -1.296 TD 0.0118 Tc 0.0064 Tw (luo a 20% dissolvida em gua destilada, injeta-)Tj T* -0.0073 Tw [(da na dose de 100 mg/kg e )10.9(a-)-31.1(cloralose \(b)-39.3(-anomer)]TJ 0 -1.308 TD 0.0109 Tc 0.09 Tw ( Sigma)Tj 6 0 0 6 347.9 122.56 Tm 0 Tc 0 Tw ()Tj 10 0 0 10 352.94 119.56 Tm 0.0114 Tc 0.0933 Tw [( CO128\) soluo preparada a partir da)]TJ -4.404 -1.296 TD 0.0093 Tc -0.0611 Tw [(mistura de 1 g de )9.2(a-)-33.6(cloralose com 100 mL de gua)]TJ T* -0.0607 Tw (destilada, aquecida a menos de 50C e adicionado)Tj /TT10 1 Tf 9 0 0 9 90.5 777.88 Tm 0.0143 Tc 0.1031 Tw [(in rats can induce a quantified plasma extravasation in 60 minutes; 2\) the pre)-39(-treatment)]TJ 0 -1.2267 TD 0.02 Tc 0.2963 Tw (with meloxicam and dexamethasone minimizes the plasma extravasation induced by)Tj 0 -1.2133 TD 0.0178 Tc 0 Tw (carrageenan.)Tj /TT9 1 Tf 0 -1.7733 TD 0.0426 Tc (UNITERMS:)Tj /TT10 1 Tf 6.3067 0 TD 0.0404 Tc 0.5711 Tw [( temporomandibular dysfunction; inflammation; carrageenan; plasma)]TJ -6.3067 -1.1067 TD 0.014 Tc 0.025 Tw (extravasation; dexamethasone; meloxicam.)Tj ET endstream endobj 20 0 obj << /ProcSet [/PDF /Text ] /Font << /TT1 4 0 R /TT2 5 0 R /TT3 6 0 R /TT8 11 0 R /TT9 12 0 R /TT10 13 0 R >> /ExtGState << /GS1 14 0 R >> /ColorSpace << /Cs6 15 0 R >> >> endobj 22 0 obj << /Length 10515 >> stream /Cs6 CS 0 0 0 SCN 0 J 0 j 0.48 w 10 M []0 d /GS1 gs 1 i 48.02 75.04 m 546.98 75.04 l S BT /TT1 1 Tf 10 0 0 10 48.02 64 Tm /Cs6 cs 0 0 0 scn 0.0107 Tc 0 Tw (356)Tj /TT2 1 Tf 8 0 0 8 66.62 64 Tm 0.0396 Tc [( )26.5( )]TJ /TT3 1 Tf 1.635 0 TD 0.0158 Tc 0.025 Tw (Revista Odonto Cincia )Tj /TT2 1 Tf 11.22 0 TD 0.0149 Tc 0.0271 Tw [( Fac. Odonto/PUCRS, v)74.9(.)0.6( 20, n. 50, out./dez. 2005)]TJ /TT3 1 Tf -15.18 92.34 TD 0.0139 Tc 0.0375 Tw (Efeito da dexametasona e do meloxicam sobre ...)Tj /TT2 1 Tf 42.57 0 TD 0.0154 Tc 0.0279 Tw [(Boleta-Ceranto DCF)120.4(, V)60.4(eiga MCF)45.4(A, Arsati F)]TJ /TT1 1 Tf 10 0 0 10 48.02 776.5601 Tm 0.0175 Tc 0.1924 Tw [(4 g de borato \(di-)-42.5(sodium-tetraborate Sigma)]TJ 6.6 0 0 6.6 280.7 779.92 Tm 0 Tc 0 Tw ()Tj 10 0 0 10 48.02 763.6 Tm 0.0117 Tc -0.0612 Tw (B9876\), at a soluo perder o aspecto leitoso, in-)Tj 0 -1.296 TD 0.0165 Tc 0.1525 Tw (jetada na dose de 50 mg/kg \(Hu)Tj 6 0 0 6 211.82 753.64 Tm 0.0222 Tc 0 Tw (14)Tj 10 0 0 10 219.26 750.64 Tm 0 Tc (,)Tj 6 0 0 6 222.5 753.64 Tm ( )Tj 10 0 0 10 225.5 750.64 Tm 0.0174 Tc 0.155 Tw (1990\). Aps)Tj -17.748 -1.308 TD 0.0118 Tc 0.0717 Tw (anestesia os animais foram submetidos ao entu-)Tj 0 -1.296 TD 0.0044 Tc -0.0613 Tw (bamento da traquia e canulao da veia femural)Tj T* 0.0066 Tc 0 Tw (direita.)Tj 1.704 -1.308 TD 0.0116 Tc 0.0683 Tw (A CA \(multiple )Tj /F4 1 Tf 7.608 0 TD 0 Tc 0 Tw ()Tj /TT1 1 Tf 0.564 0 TD (/)Tj /F4 1 Tf 0.288 0 TD ()Tj /TT1 1 Tf 0.564 0 TD 0.012 Tc 0.0675 Tw (, BDH Chemicals)Tj 6.6 0 0 6.6 239.18 701.92 Tm 0 Tc 0 Tw ()Tj 10 0 0 10 244.7 698.5601 Tm 0.0119 Tc 0.07 Tw (, UK\) foi)Tj -19.668 -1.296 TD 0.0116 Tc 0.1234 Tw (preparada como uma soluo diluda em salina)Tj T* 0.0118 Tc 0.0083 Tw (0,9% em diferentes concentraes \(100 g/50 L,)Tj 0 -1.308 TD 0.0117 Tc -0.009 Tw (300 g/50 L e 450 g/50 L\) e injetada com uma)Tj 0 -1.296 TD 0.09 Tw (agulha calibre 30, acoplada a uma microseringa)Tj T* 0.0177 Tc 0.2338 Tw (Hamilton de 50 L atravs de uma cnula de)Tj 0 -1.308 TD 0.0122 Tc 0.0841 Tw [(polietileno PE50. P)48.2(ara tanto, seguimos a tcnica)]TJ 0 -1.296 TD 0.0046 Tc -0.06 Tw (proposta por Hass et al.)Tj 6 0 0 6 160.82 610.6 Tm 0.0023 Tc 0 Tw (12 )Tj 10 0 0 10 169.58 607.6 Tm 0.0038 Tc -0.0617 Tw [(\(1992\). A borda pstero)-44.2(-)]TJ -12.156 -1.296 TD 0.0115 Tc -0.0613 Tw (inferior do arco zigomtico era palpada e a agulha)Tj 0 -1.308 TD 0.018 Tc 0.1967 Tw (inserida imediatamente inferior a este ponto e)Tj 0 -1.296 TD -0.0044 Tc -0.0607 Tw [(avanada para frente at contatar a parede pstero)-40.4(-)]TJ T* 0.0053 Tc -0.0612 Tw [(lateral do cndilo. Este contato ocorria a uma pro)-42.7(-)]TJ 0 -1.308 TD 0.0115 Tc -0.045 Tw (fundidade aproximada de 3 mm e era confirmado)Tj 0 -1.296 TD 0.0119 Tc 0.0567 Tw (pela movimentao concomitante da agulha e da)Tj T* 0.0117 Tc -0.0034 Tw [(mandbula. Em seguida realizava-)-36.3(se uma leve as)-24.3(-)]TJ 0 -1.308 TD -0.0015 Tc -0.0608 Tw [(pirao para confirmar a no injeo intravascular)106.5(,)]TJ 0 -1.296 TD 0.0118 Tc -0.03 Tw (aps isso um volume de 50 L de uma concentra-)Tj T* 0.0117 Tc 0.1072 Tw (o especfica de CA e 50 L do veculo \(salina\))Tj 0 -1.308 TD 0.0066 Tc -0.0611 Tw [(eram administrados, respectivamente, na A)54.6(TM es)-29.4(-)]TJ 0 -1.296 TD 0.0117 Tc -0.04 Tw (querda e direita.)Tj 1.704 -1.296 TD 0.0064 Tc -0.0609 Tw (Cinqenta minutos antes da morte, os animais)Tj -1.704 -1.308 TD 0.0117 Tc 0.0771 Tw (recebiam uma injeo do corante AE 1% \(Sigma)Tj 0 -1.296 TD -0.0024 Tc -0.06 Tw (Chemical Co)Tj 6 0 0 6 107.06 415.6 Tm 0 Tc 0 Tw ()Tj 10 0 0 10 112.1 412.6 Tm -0.0026 Tc -0.0613 Tw (; St Louis, MO USA\) \(30 mg/kg\) pela)Tj -6.408 -1.296 TD -0.0044 Tc -0.0608 Tw (veia femural direita que fora inicialmente canulada.)Tj 0 -1.308 TD 0.0102 Tc -0.0607 Tw [(T)83.3(odos os ratos foram mortos por perfuso carda-)]TJ 0 -1.296 TD 0.0119 Tc 0.05 Tw (ca com salina 0,9%, sob anestesia geral. Os teci-)Tj T* 0.0113 Tc 0.0213 Tw [(dos da regio da A)59.3(TM foram dissecados tanto do)]TJ 0 -1.308 TD 0.0115 Tc -0.0372 Tw (lado direito quanto do lado esquerdo, em seguida)Tj 0 -1.296 TD 0.0077 Tc -0.0611 Tw (pesados e congelados at a data de anlise. O peso)Tj T* 0.0118 Tc -0.0225 Tw [(mdio dos tecidos variou entre 38 4 mg)23.8(.)]TJ 1.704 -1.704 TD 0 Tc 0 Tw (E)Tj 8 0 0 8 72.26 304.6 Tm 0.0082 Tc (XPERIMENTO)Tj 10 0 0 10 128.3 304.6 Tm 0.007 Tc -0.06 Tw [( 01)]TJ /TT10 1 Tf 1.488 0 TD 0 Tc 0 Tw ( )Tj /TT1 1 Tf 0.252 0 TD 0.0118 Tc ( )Tj /TT10 1 Tf 0.768 0 TD 0.0085 Tc -0.0613 Tw (Estudo do tempo para an-)Tj -10.536 -1.296 TD -0.061 Tw (lise do EP induzido por CA:)Tj /TT1 1 Tf 13.152 0 TD 0.0089 Tc -0.0613 Tw [( Os ratos foram dividi-)]TJ -13.152 -1.296 TD 0.0116 Tc 0.0527 Tw (dos em 3 grupos \(n = 5\). Os animais receberam)Tj 0 -1.308 TD 0.0176 Tc 0.1894 Tw (uma injeo de 100 g/50 L de CA na regio)Tj 0 -1.296 TD 0.0115 Tc 0.0538 Tw (periarticular do lado esquerdo e 50 L de salina)Tj T* 0.0117 Tc 0.0225 Tw (0,9% no lado contralateral, que correspondeu ao)Tj 0 -1.308 TD 0.0043 Tw (grupo controle. O sacrifcio dos animais foi reali-)Tj 0 -1.296 TD 0.0118 Tc -0.051 Tw [(zado 60, 120 e 180 minutos aps a injeo de CA)-24.2(,)]TJ T* 0.0181 Tc 0.2075 Tw (respectivamente ao grupo que pertenciam, e o)Tj 0 -1.308 TD 0.0119 Tc 0.0114 Tw (corante AE foi injetado sempre 50 minutos antes)Tj 0 -1.296 TD 0.0111 Tc -0.035 Tw (da morte.)Tj 1.704 -1.584 TD 0 Tc 0 Tw (E)Tj 8 0 0 8 72.38 158.8 Tm 0.0132 Tc (XPERIMENTO)Tj 10 0 0 10 128.78 158.8 Tm 0.0123 Tc 0.0946 Tw [( 02 )]TJ /TT10 1 Tf 2.988 0 TD 0.0117 Tc 0.0949 Tw [(Estudo dose)-24.3(-resposta: )]TJ /TT1 1 Tf 11.46 0 TD 0.013 Tc 0 Tw (Os)Tj -22.524 -1.296 TD 0.0115 Tc 0.0506 Tw (animais foram divididos em 04 grupos \(n = 6\) e)Tj 0 -1.308 TD 0.012 Tc 0.1215 Tw (tratados como no experimento 01, exceto que a)Tj 0 -1.296 TD 0.0178 Tc 0.1969 Tw [(dose resposta foi determinada injetando)-30.2(-)-37.1(se di-)]TJ T* 0.0115 Tc 0.0413 Tw [(ferentes concentraes de CA \(100 g)11.5(, 300 g ou)]TJ 0 -1.308 TD -0.0003 Tc -0.0612 Tw [(450 g/50 L\) ou salina na regio periarticular)107.7(, res)-24.3(-)]TJ 26.088 68.28 TD 0.0119 Tc 0.0374 Tw [(pectivamente, na A)59.9(TM direita e esquerda. Basea-)]TJ 0 -1.296 TD 0.0117 Tc 0.0585 Tw (do nos resultados do experimento 01, que sero)Tj T* 0.0049 Tc -0.061 Tw (posteriormente apresentados, aps 10 minutos da)Tj 0 -1.308 TD 0.0117 Tc 0.1125 Tw (injeo de CA foi realizada a injeo do corante)Tj 0 -1.296 TD 0.0019 Tc -0.061 Tw [(AE. Sessenta minutos aps a injeo de CA)-10.1(, os ani-)]TJ T* 0.0116 Tc -0.03 Tw (mais foram mortos.)Tj 1.692 -1.608 TD 0 Tc 0 Tw (E)Tj 8 0 0 8 333.14 695.5601 Tm 0.0132 Tc (XPERIMENTO)Tj 10 0 0 10 389.54 695.5601 Tm 0.0129 Tc 0.0817 Tw [( 03 )]TJ /TT10 1 Tf 2.94 0 TD 0.0117 Tc 0.0825 Tw [(Estudo do efeito das dro)-36.3(-)]TJ -11.004 -1.32 TD -0.055 Tw (gas antiinflamatrias: )Tj /TT1 1 Tf 11.292 0 TD 0.0114 Tc -0.0583 Tw (Aps padronizados o tem-)Tj -11.292 -1.32 TD 0.0117 Tc 0.0649 Tw (po e a concentrao de CA ideais para o estudo,)Tj T* 0.0114 Tc -0.0185 Tw [(analisou-)-36.6(se os efeitos da Dexametasona \(DEX)23.4(A\) e)]TJ T* -0.0087 Tw (do Meloxicam \(MEL\) sobre o EP induzido por CA)Tj T* 0.0117 Tc -0.0532 Tw (300 g/50 L no tempo de 60 minutos \(resultados)Tj T* -0.0431 Tw (dos experimentos 01 e 02\). Os ratos foram dividi-)Tj T* -0.0505 Tw (dos em 7 grupos \(n = 5\), e receberam, respectiva-)Tj T* 0.0181 Tc 0.28 Tw (mente ao grupo que pertenciam, uma injeo)Tj T* 0.0114 Tc -0.045 Tw [(intraperitoneal de diferentes doses de DEX)23.4(A \(2,3;)]TJ T* 0.0388 Tw (4,6 e 6,9 mg/kg\) e de MEL \(7, 14 e 21 mg/kg\) ou)Tj T* 0.0119 Tc -0.0186 Tw (salina 0,9% em um volume correspondente ao do)Tj T* -0.0438 Tw (tratamento \(cerca de 0,9 mL\), 2h antes da injeo)Tj T* 0.0177 Tc 0.2571 Tw (periarticular de CA 300 g/50 L, os animais)Tj T* 0.0117 Tc -0.0031 Tw [(foram mortos aps 60 minutos da injeo de CA)-12.3(.)]TJ T* -0.0375 Tw (A injeo endovenosa de AE atravs da veia femu-)Tj T* 0.1378 Tw (ral canulada, foi realizada 50 minutos antes da)Tj T* 0.005 Tc 0 Tw (morte.)Tj /TT8 1 Tf 11 0 0 11 308.9 446.44 Tm 0.0098 Tc 0.0091 Tw (Medida do extravasamento plasmtico do)Tj 0 -1.2 TD 0.0096 Tc -0.003 Tw (corante azul de Evans)Tj /TT1 1 Tf 10 0 0 10 325.82 414.64 Tm 0.0114 Tc 0.0536 Tw (O corante AE foi extrado atravs da imerso)Tj -1.692 -1.32 TD 0.018 Tc 0.2843 Tw (do tecido em 1 mL de formamida, em tubos)Tj T* 0.0115 Tc 0.1242 Tw (epperdorf, mantidos temperatura de 60C em)Tj T* 0.0117 Tc -0.0029 Tw [(banho)-36.3(-maria por um perodo de 24 h \(F)23.7(iorentino)]TJ T* 0.0114 Tc -0.015 Tw (et al.)Tj 6 0 0 6 332.42 364.84 Tm 0 Tc 0 Tw (8)Tj 10 0 0 10 336.14 361.84 Tm (,)Tj 6 0 0 6 339.26 364.84 Tm ( )Tj 10 0 0 10 341.18 361.84 Tm 0.0113 Tc -0.0185 Tw (1999\). A quantidade do corante AE \(g\) no)Tj -3.228 -1.32 TD 0.0082 Tc -0.0612 Tw [(tecido periariticular foi determinada utilizando)-39.8(-)-34.7(s)-1.7(e)]TJ T* 0.0118 Tc 0.05 Tw (um espectrofotmetro \(Anthos 2020, verso 1.2\))Tj T* 0.0004 Tc -0.0607 Tw (que media a absorbncia da soluo de formamida)Tj T* 0 Tc 0 Tw (\()Tj /TT10 1 Tf 0.348 0 TD (v)Tj /TT1 1 Tf 0.552 0 TD 0.0117 Tc 0.0622 Tw [( = 620 nm\). A concentrao do corante AE foi)]TJ -0.9 -1.32 TD -0.0292 Tw (ento calculada por grama de tecido periarticular)Tj T* 0.0066 Tc 0 Tw (pesado.)Tj /TT8 1 Tf 11 0 0 11 308.9 257.68 Tm 0.0097 Tc -0.0137 Tw (Anlise estatstica)Tj /TT1 1 Tf 10 0 0 10 325.82 238.36 Tm 0.0116 Tc -0.0337 Tw [(Utilizou-)-36.4(se o programa estatstico Sigma-)-24.4(Stat.)]TJ -1.692 -1.32 TD 0.0429 Tw [(P)41.9(ara o EP a varivel dependente foi determinada)]TJ T* 0.0119 Tc 0.0283 Tw (pela comparao entre o tecido periarticular que)Tj T* -0.0273 Tw [(recebeu CA e o que recebeu salina do mesmo ani-)]TJ T* 0.0113 Tc 0.0667 Tw (mal atravs da quantidade em microgramas \(g\))Tj T* 0.0116 Tc 0.001 Tw (de AE por grama \(g\) de tecido, e foi avaliado pelo)Tj T* 0.0308 Tw [(teste de Anlise de V)107.5(arincia \(ANO)23.5(V)79.5(A\), com valo)-36.5(-)]TJ T* 0.0108 Tc 0.015 Tw (res de )Tj /TT10 1 Tf 3.3 0 TD 0.016 Tc 0 Tw (p )Tj /TT1 1 Tf 0.948 0 TD 0.012 Tc 0.015 Tw (< 0,05, considerados como sendo signi-)Tj -4.248 -1.32 TD 0.0721 Tw (ficantes. Na presena de significncia, o teste de)Tj T* 0.0118 Tc 0.0167 Tw [(T)108.9(ukey foi utilizado para identificar as diferenas.)]TJ T* -0.0599 Tw [(Comparao mltipla foi realizada aplicando)-24.2(-)-43.1(se o)]TJ T* 0.012 Tc -0.035 Tw (teste de Dunn.)Tj ET endstream endobj 23 0 obj << /ProcSet [/PDF /Text ] /Font << /F4 24 0 R /TT1 4 0 R /TT2 5 0 R /TT3 6 0 R /TT8 11 0 R /TT10 13 0 R >> /ExtGState << /GS1 14 0 R >> /ColorSpace << /Cs6 15 0 R >> >> endobj 26 0 obj << /Length 15041 >> stream /Cs6 CS 0 0 0 SCN 0 J 0 j 0.48 w 10 M []0 d /GS1 gs 1 i 48.02 75.04 m 546.98 75.04 l S BT /TT3 1 Tf 8 0 0 8 238.7 64 Tm /Cs6 cs 0 0 0 scn 0.015 Tc 0.0208 Tw (Revista Odonto Cincia )Tj /TT2 1 Tf 11.205 0 TD 0.0145 Tc [( Fac. Odonto/PUCRS, v. 20, n. 50, out./dez. 2005 )]TJ /TT1 1 Tf 10 0 0 10 528.38 64 Tm 0.0167 Tc 0 Tw (357)Tj /TT3 1 Tf 8 0 0 8 48.02 802.72 Tm 0.0139 Tc 0.0375 Tw (Efeito da dexametasona e do meloxicam sobre ...)Tj /TT2 1 Tf 42.57 0 TD 0.0154 Tc 0.0279 Tw [(Boleta-Ceranto DCF)120.4(, V)60.4(eiga MCF)45.4(A, Arsati F)]TJ /TT8 1 Tf 11 0 0 11 48.02 775.96 Tm 0.0133 Tc 0 Tw [(RESUL)89.7(T)61.6(ADOS)]TJ /TT1 1 Tf 10 0 0 10 65.06 759.04 Tm 0.0179 Tc 0.2119 Tw [(Os resultados do Experimento 01 demons)-18.1(-)]TJ -1.704 -1.248 TD 0.0177 Tc 0.2528 Tw [(traram que o EP do corante AE utilizando)-42.3(-)-37.2(s)-4.3(e)]TJ T* 0.0074 Tc -0.06 Tw (CA 100)Tj 8 0 0 10 83.06 734.08 Tm 0 Tc 0 Tw ( )Tj 10 0 0 10 87.98 734.08 Tm 0.0101 Tc (g/50)Tj 8 0 0 10 113.78 734.08 Tm 0 Tc ( )Tj 10 0 0 10 118.7 734.08 Tm 0.0101 Tc -0.0616 Tw (L, foi estatisticamente significante)Tj -7.068 -1.248 TD 0.0117 Tc 0.0871 Tw (\(p < 0,05\) comparado ao lado contralateral que)Tj T* 0.0108 Tc -0.0612 Tw (recebeu a injeo de salina, no tempo de 60 minu-)Tj T* 0.0106 Tc -0.0607 Tw (tos, em relao aos demais tempos, como mostra-)Tj 0 -1.26 TD 0.0114 Tc -0.0178 Tw [(do na F)11.4(igura 1 e T)71.4(abela 1.)]TJ 1.704 -1.248 TD -0.0081 Tc -0.05 Tw [(O Experimento 02 investigou o parmetro dose)-32.1(-)]TJ -1.704 -1.248 TD 0.0115 Tc 0.0275 Tw (dependncia. A diferena na dose de CA entre os)Tj T* 0.0113 Tc -0.0605 Tw [(lados tratado e controle so mostrado na F)11.3(igura 2)]TJ T* 0.0079 Tc -0.0614 Tw [(e T)67.9(abela 2. T)91.9(este de comparao mltipla \(teste )-16.3(d)16.9(e)]TJ ET q 69.86 622.12 194.52 -91.2 re W n q 195.12 0 0 -101.88 69.86 631.36 cm /Im1 Do Q Q BT 9 0 0 9 48.02 518.08 Tm 0.0142 Tc -0.0333 Tw [(F)8(igura 1 EP \(g/g\) induzido por CA 100 g/50 L, nos)]TJ 0 -1.1067 TD 0.0151 Tc 0.0222 Tw (perodos de 60, 120 e 180 minutos e seus respectivos)Tj 0 -1.12 TD 0.005 Tc -0.061 Tw [(controles \(salina 0,9%\). T)85(este T)98.3(ukey pareado \(p < 0,05\).)]TJ 0 -1.1067 TD 0.0146 Tc 0.0068 Tw [(Os valores representam a mdia desvio)-38.7(-padro.)]TJ 0 -2.56 TD 0.0081 Tc 0.052 Tw [(T)66.5(ABELA 1 V)114.8(alores mdios do EP \(g/g\) induzido por)]TJ 0 -1.1067 TD 0.0086 Tc -0.054 Tw [(CA 100 g/50 L e seus respectivos desvios)-18.1(-padro, nos)]TJ T* -0.0426 Tw (diferentes tempos estudados. Os valores representam a)Tj 0 -1.12 TD 0.008 Tc 0.0089 Tw [(mdia desvio)-45.3(-padro.)]TJ ET q 73.34 331.36 187.56 -88.08 re W n q 195.6369 0 0 -92.3028 68.7954 333.3595 cm /Im2 Do Q Q BT 9 0 0 9 48.02 231.16 Tm 0.0198 Tc 0.1527 Tw [(F)13.6(igura 2 Extravasamento plasmtico induzido por)]TJ 0 -1.1067 TD 0.0163 Tc (diferentes concentraes de carragenina \(100, 300 e)Tj 0 -1.12 TD 0.0046 Tc -0.061 Tw [(450 g/50 L\) em 60 minutos. T)84.6(este de Dunn \(p < 0,05\).)]TJ 0 -2.7067 TD 0.0081 Tc 0.052 Tw [(T)66.5(ABELA 2 V)114.8(alores mdios do EP \(g/g\) induzido por)]TJ 0 -1.1067 TD -0.0121 Tc 0 Tw (CA)Tj 7.2 0 0 9 60.14 176.8 Tm 0 Tc ( )Tj 9 0 0 9 61.94 176.8 Tm -0.0125 Tc (100,)Tj 7.2 0 0 9 80.66 176.8 Tm 0 Tc ( )Tj 9 0 0 9 82.46 176.8 Tm -0.0133 Tc -0.0811 Tw [(300 e)24.4( 450)]TJ 6.3 0 0 9 122.66 176.8 Tm 0 Tc 0 Tw ( )Tj 9 0 0 9 124.1 176.8 Tm -0.0149 Tc (g/50)Tj 6.3 0 0 9 146.3 176.8 Tm 0 Tc ( )Tj 9 0 0 9 147.86 176.8 Tm -0.0119 Tc -0.0555 Tw (L e salina 0,9%, juntamente com)Tj -11.0933 -1.1067 TD -0.0124 Tc 0.1078 Tw [(seus respectivos desvios)-25.7(-padro, no tempo de 60 minu-)]TJ 0 -1.12 TD -0.0126 Tc 0.0066 Tw [(tos. Os valores representam a mdia desvio)-39.3(-padro.)]TJ /TT12 1 Tf 8.16 0 0 8.16 92.54 138.0397 Tm -0.0124 Tc 0 Tw [(Gr)-9.7(upo)-12.4(s)]TJ /TT11 1 Tf 3.1618 0 TD 0 Tc ( )Tj /TT12 1 Tf 7.0147 0 TD 0.0003 Tc 4.8968 Tw [(N)16.6( E)5.5(P)8.2( )4897.1(\()9.8()2.9(g/g\))]TJ /TT11 1 Tf 9.8676 0 TD 0 Tc 0 Tw ( )Tj ET 48.02 146.8 114.84 0.48 re f q 48.02 147.28 238.08 -65.88 re W n 1 J 1 j 0.12 w 48.02 147.28 m 162.86 147.28 l S Q 162.86 146.8 0.48 0.48 re f q 48.02 147.28 238.08 -65.88 re W n 1 J 1 j 0.12 w 162.86 147.28 m 163.34 147.28 l 162.86 147.28 m 162.86 146.8 l S Q 163.34 146.8 30.12 0.48 re f q 48.02 147.28 238.08 -65.88 re W n 1 J 1 j 0.12 w 163.34 147.28 m 193.46 147.28 l S Q 193.46 146.8 0.48 0.48 re f q 48.02 147.28 238.08 -65.88 re W n 1 J 1 j 0.12 w 193.46 147.28 m 193.94 147.28 l 193.46 147.28 m 193.46 146.8 l S Q 193.94 146.8 91.2 0.48 re f q 48.02 147.28 238.08 -65.88 re W n 1 J 1 j 0.12 w 193.94 147.28 m 285.14 147.28 l S Q BT 8.16 0 0 8.16 53.06 125.5597 Tm -0.0005 Tc 0.0005 Tw [(S)11.5(a)2.2(l)12.6(i)-2.1(na 0,9%)9( )-9823.5(05 )-4352.9( 6,4 0,82 )]TJ ET 48.02 134.32 114.84 0.24 re f q 48.02 147.28 238.08 -65.88 re W n 1 J 1 j 0.12 w 48.02 134.56 m 162.86 134.56 l S Q 162.86 134.32 0.24 0.24 re f 1 J 1 j 0.12 w 162.86 134.56 m 163.1 134.56 l 162.86 134.56 m 162.86 134.32 l S 163.1 134.32 30.36 0.24 re f 163.1 134.56 m 193.46 134.56 l S 193.46 134.32 0.24 0.24 re f 193.46 134.56 m 193.7 134.56 l 193.46 134.56 m 193.46 134.32 l S 193.7 134.32 91.44 0.24 re f 193.7 134.56 m 285.14 134.56 l S BT 8.16 0 0 8.16 53.06 114.9997 Tm -0.0006 Tc 0.0006 Tw [(C)4.6(A)30.4( 100 g)14.1(/50 )14.7(L)36.7( )-7544.1(05 )-4235.3(15,29 3,13 )]TJ 0 -1.3088 TD [(C)4.6(A)30.4( 300 g)14.1(/50 )14.7(L)36.7( )-7544.1(05 )-3485.3( 26,13 5,98 *)14.1( )]TJ 0 -1.2941 TD -0.0005 Tc 0.0005 Tw [(C)4.7(A)30.5( 450 g)14.2(/50 )14.7(L)36.8( )-7544.1(05 )-3485.3( 32,42 4,88)14.2( * )]TJ ET 48.02 90.04 114.84 0.48 re f q 48.02 147.28 238.08 -65.88 re W n 48.02 90.52 m 162.86 90.52 l S Q 162.86 90.04 0.48 0.48 re f 162.86 90.52 m 163.34 90.52 l 162.86 90.52 m 162.86 90.04 l S 163.34 90.04 30.12 0.48 re f 163.34 90.52 m 193.46 90.52 l S 193.46 90.04 0.48 0.48 re f 193.46 90.52 m 193.94 90.52 l 193.46 90.52 m 193.46 90.04 l S 193.94 90.04 91.2 0.48 re f 193.94 90.52 m 285.14 90.52 l S q 327.02 619.36 201.72 -88.08 re W n q 208.2461 0 0 -92.3822 324.5 621.537 cm /Im3 Do Q Q BT /TT1 1 Tf 9 0 0 9 308.9 517.24 Tm 0.0148 Tc -0.0132 Tw [(F)21.9(igura 3 Efeito da administrao de diferentes doses)]TJ 0 -1.1067 TD 0.0206 Tc 0.155 Tw (de dexametasona \(2,3; 4,6 e 6,9 mg/kg\) sobre o EP)Tj 0 -1.12 TD 0.0146 Tc 0.0055 Tw [(induzido por CA 300 g)41.3(.)]TJ 0 -3.5333 TD 0.0087 Tc -0.0167 Tw [(T)67.1(ABELA 3 Efeito da administrao intraperitoneal de)]TJ 0 -1.12 TD 0.0085 Tc -0.0071 Tw (diferentes doses de dexametasona sobre o EP induzido)Tj 0 -1.1067 TD 0.1438 Tw [(pela administrao de CA \(300 g\) na A)75.2(TM de ratos.)]TJ T* 0.008 Tc 0.0091 Tw [(Dados expressos como mdia desvio)-32(-padro.)]TJ /TT12 1 Tf 8.04 0 0 8.04 355.82 416.2004 Tm -0.003 Tc 0 Tw [(Gr)-6.9(upo)-10.5(s)]TJ /TT11 1 Tf 3.2239 -0.0001 TD 0 Tc ( )Tj /TT12 1 Tf 7.1045 0.0001 TD -0.006 Tc 4.9799 Tw [(N E)-10.7(P)-7.1( )4970.2(\()-11.9(g)-13.5(/)-11.8(g\))]TJ /TT11 1 Tf 10 -0.0001 TD 0 Tc 0 Tw ( )Tj ET 310.7 425.32 115.44 0.48 re f 310.7 425.8 m 426.14 425.8 l S 426.14 425.32 0.48 0.48 re f 426.14 425.8 m 426.62 425.8 l 426.14 425.8 m 426.14 425.32 l S 426.62 425.32 30.12 0.48 re f 426.62 425.8 m 456.74 425.8 l S 456.74 425.32 0.48 0.48 re f 456.74 425.8 m 457.22 425.8 l 456.74 425.8 m 456.74 425.32 l S 457.22 425.32 89.76 0.48 re f q 308.9 428.08 238.08 -64.44 re W n 457.22 425.8 m 546.98 425.8 l S Q BT 8.04 0 0 8.04 316.46 403.3594 Tm 0.0062 Tc -0.0025 Tw [(S)10.1(a)2.3(l)15.4(i)0.4(na 0,9)13.7(%)3.4( )-10223.9(5 )-4298.5( 23,91 )17.7( 3,08 )]TJ ET 310.7 412 115.44 0.24 re f 310.7 412.24 m 426.14 412.24 l S 426.14 412 0.24 0.24 re f 426.14 412.24 m 426.38 412.24 l 426.14 412.24 m 426.14 412 l S 426.38 412 30.36 0.24 re f 426.38 412.24 m 456.74 412.24 l S 456.74 412 0.24 0.24 re f 456.74 412.24 m 456.98 412.24 l 456.74 412.24 m 456.74 412 l S 456.98 412 90 0.24 re f q 308.9 428.08 238.08 -64.44 re W n 456.98 412.24 m 546.98 412.24 l S Q BT 8.04 0 0 8.04 316.46 391.4794 Tm 0.0065 Tc -0.0028 Tw [(D)12.2(E)5.4(X)12.2(A)27.2( 2,)17.7(3 m)8.2(g)14(/kg)14( )-8015(5 )-4806(23,51 )14.9( 6,9 )]TJ 0 -1.4925 TD 0.0062 Tc -0.0025 Tw [(D)11.9(E)5.1(X)11.9(A)26.9( 4,)17.4(6 m)7.9(g)13.7(/kg)13.7( )-8015(5 )-3925.4( 15,97 )14.9( 1,63*)13.7( )]TJ T* [(D)11.9(E)5.1(X)11.9(A)26.9( 6,)17.4(9 m)7.9(g)13.7(/kg)13.7( )-8015(5 )-3925.4( 15,56 )14.9( 2,27*)13.7( )]TJ ET 310.7 363.64 115.44 0.48 re f q 308.9 428.08 238.08 -64.44 re W n 310.7 364.12 m 426.14 364.12 l S Q 426.14 363.64 0.48 0.48 re f q 308.9 428.08 238.08 -64.44 re W n 426.14 364.12 m 426.62 364.12 l 426.14 364.12 m 426.14 363.64 l S Q 426.62 363.64 30.12 0.48 re f q 308.9 428.08 238.08 -64.44 re W n 426.62 364.12 m 456.74 364.12 l S Q 456.74 363.64 0.48 0.48 re f q 308.9 428.08 238.08 -64.44 re W n 456.74 364.12 m 457.22 364.12 l 456.74 364.12 m 456.74 363.64 l S Q 457.22 363.64 89.76 0.48 re f q 308.9 428.08 238.08 -64.44 re W n 457.22 364.12 m 546.98 364.12 l S Q q 319.94 331.12 200.52 -87.84 re W n q 201.12 0 0 -100.56 319.94 334 cm /Im4 Do Q Q BT /TT1 1 Tf 9 0 0 9 308.9 231.16 Tm 0.0148 Tc -0.0132 Tw [(F)21.9(igura 4 Efeito da administrao de diferentes doses)]TJ 0 -1.1067 TD 0.0355 Tw (de meloxicam \(7, 14 e 21 mg/kg\) sobre o EP induzido)Tj 0 -1.12 TD 0.0136 Tc 0.0019 Tw [(por CA 300 g)26.9(.)]TJ 10 0 0 10 308.9 776.6801 Tm -0.0084 Tc 0.0991 Tw (Dunn\) demonstrou que entre as concentraes de)Tj 0 -1.296 TD 0.0117 Tc 0.03 Tw (CA utilizadas, somente as de 300 e 450 g/50 L)Tj 0 -1.284 TD 0.0119 Tc 0.0884 Tw [(foram estatisticamente significantes \(p < 0,05\),)]TJ 0 -1.296 TD -0.0525 Tw (comparadas ao controle.)Tj 1.692 -1.404 TD 0.0176 Tc 0.169 Tw (O estudo farmacolgico demonstrou que as)Tj -1.692 -1.284 TD 0.0096 Tc -0.0612 Tw (drogas antiinflamatrias utilizadas somente redu-)Tj 0 -1.296 TD 0.0117 Tc -0.0075 Tw (ziram o EP causado pela administrao peri-arti-)Tj 0 -1.284 TD 0.0114 Tc 0.0838 Tw (cular de CA \(300 g/50 L\) de forma estatistica-)Tj T* 0.0084 Tc -0.0612 Tw (mente significante \(p < 0,05\) em altas doses: MEL)Tj 0 -1.272 TD 0.0115 Tc -0.0521 Tw [(14 e 21 mg/kg)23.5(, dados demonstrados na F)23.5(igura 3 e)]TJ 0 -1.284 TD 0.0118 Tc -0.0155 Tw [(T)84.9(abela 3 e DEX)11.8(A 4,6 e 6,9 mg/kg)23.8(, dados demons)-12.2(-)]TJ T* 0.0112 Tc -0.0169 Tw [(trados na F)23.2(igura 4 e T)59.2(abela 4.)]TJ /TT12 1 Tf 8.04 0 0 8.04 91.46 416.9204 Tm -0.003 Tc 0 Tw [(Gr)-6.9(upo)-10.5(s)]TJ /TT11 1 Tf 3.2239 -0.0001 TD 0 Tc ( )Tj /TT12 1 Tf 7.3433 0.0001 TD 0.0066 Tc 5.3255 Tw [(N EP)5.5( )5328.4(\()11.3()0.7(g/g\))]TJ /TT11 1 Tf 10.3881 -0.0001 TD 0 Tc 0 Tw ( )Tj ET 49.1 425.56 109.92 0.48 re f 49.1 426.04 m 159.02 426.04 l S 159.02 425.56 0.48 0.48 re f 159.02 426.04 m 159.5 426.04 l 159.02 426.04 m 159.02 425.56 l S 159.5 425.56 39.48 0.48 re f 159.5 426.04 m 198.98 426.04 l S 198.98 425.56 0.48 0.48 re f 198.98 426.04 m 199.46 426.04 l 198.98 426.04 m 198.98 425.56 l S 199.46 425.56 87.48 0.48 re f q 48.02 427.72 238.92 -81 re W n 199.46 426.04 m 286.94 426.04 l S Q BT 8.04 0 0 8.04 54.86 404.6794 Tm 0.0062 Tc -0.0025 Tw [(CA)26.9(100 g)13.7(/60 )-15(m)7.9(i)0.5(n )-7358.2(05)-16.2( )-3910.5( 15,29 3,50)-16.2( *)28.6( )]TJ ET 49.1 413.32 109.92 0.24 re f 49.1 413.56 m 159.02 413.56 l S 159.02 413.32 0.24 0.24 re f 159.02 413.56 m 159.26 413.56 l 159.02 413.56 m 159.02 413.32 l S 159.26 413.32 39.72 0.24 re f 159.26 413.56 m 198.98 413.56 l S 198.98 413.32 0.24 0.24 re f 198.98 413.56 m 199.22 413.56 l 198.98 413.56 m 198.98 413.32 l S 199.22 413.32 87.72 0.24 re f q 48.02 427.72 238.92 -81 re W n 199.22 413.56 m 286.94 413.56 l S Q BT 8.04 0 0 8.04 54.86 394.1194 Tm 0.0065 Tc -0.0028 Tw [(S)10.4(a)2.6(l)15.7(i)0.8(na/60 m)8.2(i)0.8(n)-15.9( )-9074.7(05)-15.9( )-4656.7(5,722 0,36 )]TJ 0 -1.2985 TD [(CA)27.2(100 g)14(/120)-15.9( m)8.2(i)0.8(n )-6850.8(05)-15.9( )-4656.7(1,418 0,34 )]TJ 0 -1.3134 TD 0.0062 Tc -0.0025 Tw [(S)10.1(a)2.3(l)15.4(i)0.5(na/120 m)7.9(i)0.4(n)-16.2( )-8567.2(05)-16.2( )-4656.7( 1,65 0,53 )]TJ 0 -1.2985 TD 0.0065 Tc -0.0028 Tw [(CA)27.2(100 g)14(/180)-15.9( m)8.2(i)0.8(n )-6850.8(05)-15.9( )-4656.7(2,318 0,41 )]TJ 0 -1.3134 TD 0.0062 Tc -0.0025 Tw [(S)10.1(a)2.3(l)15.4(i)0.5(na/180 m)7.9(i)0.4(n)-16.2( )-8567.2(05)-16.2( )-4656.7( 2,24 0,51 )]TJ ET 0 J 0 j 0.48 w 48.02 349.24 m 286.1 349.24 l S BT /TT1 1 Tf 9 0 0 9 308.9 186.76 Tm 0.0087 Tc -0.0167 Tw [(T)67.1(ABELA 4 Efeito da administrao intraperitoneal de)]TJ 0 -1.1067 TD 0.2285 Tw (diferentes doses de meloxicam sobre o EP induzido)Tj T* 0.0085 Tc 0.1438 Tw [(pela administrao de CA \(300 g\) na A)75.2(TM de ratos.)]TJ 0 -1.12 TD 0.008 Tc 0.0091 Tw [(Dados expressos como mdia desvio)-32(-padro.)]TJ /TT12 1 Tf 8.04 0 0 8.04 354.38 138.0404 Tm -0.003 Tc 0 Tw [(Gr)-6.9(upo)-10.5(s)]TJ /TT11 1 Tf 3.2239 -0.0001 TD 0 Tc ( )Tj /TT12 1 Tf 7.1045 0.0001 TD -0.0059 Tc 4.9798 Tw [(N E)-10.6(P)-7( )4970.2(\()-11.8(g)-13.4(/)-11.6(g\))]TJ /TT11 1 Tf 10 -0.0001 TD 0 Tc 0 Tw ( )Tj ET 309.26 146.68 115.44 0.48 re f q 308.9 149.2 238.08 -58.44 re W n 1 J 1 j 0.12 w 309.26 147.16 m 424.7 147.16 l S Q 424.7 146.68 0.48 0.48 re f 1 J 1 j 0.12 w 424.7 147.16 m 425.18 147.16 l 424.7 147.16 m 424.7 146.68 l S 425.18 146.68 30.12 0.48 re f 425.18 147.16 m 455.3 147.16 l S 455.3 146.68 0.48 0.48 re f 455.3 147.16 m 455.78 147.16 l 455.3 147.16 m 455.3 146.68 l S 455.78 146.68 91.2 0.48 re f q 308.9 149.2 238.08 -58.44 re W n 455.78 147.16 m 546.98 147.16 l S Q BT 8.04 0 0 8.04 315.02 125.6794 Tm 0.0062 Tc -0.0025 Tw [(S)10.1(a)2.3(l)15.4(i)0.4(na 0,9)13.7(%)3.4( )-10223.9(5 )-4552.3(23,91 3)13.7(,)2.5(08 )]TJ ET 309.26 134.32 115.44 0.24 re f q 308.9 149.2 238.08 -58.44 re W n 309.26 134.56 m 424.7 134.56 l S Q 424.7 134.32 0.24 0.24 re f 424.7 134.56 m 424.94 134.56 l 424.7 134.56 m 424.7 134.32 l S 424.94 134.32 30.36 0.24 re f 424.94 134.56 m 455.3 134.56 l S 455.3 134.32 0.24 0.24 re f 455.3 134.56 m 455.54 134.56 l 455.3 134.56 m 455.3 134.32 l S 455.54 134.32 91.44 0.24 re f q 308.9 149.2 238.08 -58.44 re W n 455.54 134.56 m 546.98 134.56 l S Q BT 8.04 0 0 8.04 315.02 115.2394 Tm 0.0067 Tc -0.003 Tw [(Me)17.7(l)15.9( 7 m)8.4(g)29.1(/kg)14.2( )-9925.4(5 )-4552.3(21,77 4)14.2(,)3(42 )]TJ 0 -1.3134 TD 0.0065 Tc -0.0028 Tw [(Me)17.5(l)15.7( 14 m)23.1(g)14(/kg)14( )-9417.9(5 )-4044.8( 18,27 )18( 2,82*)14( )]TJ 0 -1.2985 TD 0.0069 Tc -0.0032 Tw [(Me)17.9(l)16.1( 21 m)23.5(g)14.4(/kg)14.4( )-9417.9(5 )-4044.8(16,696 )18.4( 2,16*)14.4( )]TJ ET 309.26 90.76 115.44 0.12 re f q 308.9 149.2 238.08 -58.44 re W n 309.26 90.88 m 424.7 90.88 l S Q 424.7 90.76 0.48 0.12 re f q 308.9 149.2 238.08 -58.44 re W n 424.7 90.88 m 425.18 90.88 l 424.7 90.88 m 424.7 90.76 l S Q 425.18 90.76 30.12 0.12 re f q 308.9 149.2 238.08 -58.44 re W n 425.18 90.88 m 455.3 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l S BT /TT1 1 Tf 10 0 0 10 48.02 64 Tm /Cs6 cs 0 0 0 scn 0.0107 Tc 0 Tw (358)Tj /TT2 1 Tf 8 0 0 8 66.62 64 Tm 0.0396 Tc [( )26.5( )]TJ /TT3 1 Tf 1.635 0 TD 0.0158 Tc 0.025 Tw (Revista Odonto Cincia )Tj /TT2 1 Tf 11.22 0 TD 0.0149 Tc 0.0271 Tw [( Fac. Odonto/PUCRS, v)74.9(.)0.6( 20, n. 50, out./dez. 2005)]TJ /TT3 1 Tf -15.18 92.34 TD 0.0139 Tc 0.0375 Tw (Efeito da dexametasona e do meloxicam sobre ...)Tj /TT2 1 Tf 42.57 0 TD 0.0154 Tc 0.0279 Tw [(Boleta-Ceranto DCF)120.4(, V)60.4(eiga MCF)45.4(A, Arsati F)]TJ /TT8 1 Tf 11 0 0 11 48.02 775.12 Tm 0.012 Tc 0 Tw (DISCUSSO)Tj /TT1 1 Tf 10 0 0 10 65.06 754.12 Tm 0.0176 Tc 0.168 Tw [(Baseados nas medidas inflamatrias do EP)257.6(,)]TJ -1.704 -1.32 TD 0.0003 Tc -0.0608 Tw (nossos achados mostram que um modelo orofacial)Tj T* 0.0114 Tc 0.1043 Tw (de inflamao aguda pode ser criado atravs da)Tj T* 0.0262 Tw [(injeo peri-articular de CA na regio da A)47.5(TM de)]TJ T* 0.01 Tc -0.0609 Tw (ratos anestesiados. Esta rea foi selecionada devi-)Tj T* 0.0117 Tc -0.0262 Tw (do ao fato de as DTMs serem uma importante en-)Tj T* 0.0115 Tc -0.0143 Tw (tidade clnica. As DTMs tm uma grande varieda-)Tj T* 0.0117 Tc -0.0425 Tw (de de fatores etiolgicos, dos quais um deles rela-)Tj T* 0.0119 Tc 0.0091 Tw [(ciona-)-36.1(se a processos inflamatrios. Estes tecidos)]TJ T* 0.0983 Tw (so inervados pelo nervo trigmeo, que tambm)Tj T* 0.0116 Tc 0.015 Tw (fornece inervao sensorial s estruturas dentais)Tj T* 0.0119 Tc 0.0093 Tw (e orais, de forma que este modelo tem relevncia)Tj T* -0.0035 Tc -0.0607 Tw [(a estudos odontolgicos. Acrescenta-)-39.5(se a isso o fato)]TJ T* 0.0118 Tc 0.0343 Tw [(de que a inflamao na A)59.8(TM de um lado poderia)]TJ T* 0.0116 Tc -0.03 Tw (ser comparado ao lado contralateral no inflama-)Tj T* 0.0111 Tc -0.0611 Tw (do, o que possibilita que o animal seja controle de)Tj T* 0.0118 Tc -0.055 Tw (si prprio.)Tj 1.704 -1.32 TD 0.0114 Tc 0.067 Tw (Numerosos agentes so utilizados para indu-)Tj -1.704 -1.32 TD 0.0119 Tc 0.095 Tw [(zir inflamao em ratos, incluindo leo de mos)-24.1(-)]TJ T* 0.0117 Tc 0.0675 Tw (tarda, formalina, cido actico, fator de ativao)Tj T* 0.0509 Tw [(plaquetria e carragenina \(Wheeler)35.7(-)16.8(Aceto et al.)]TJ 6 0 0 6 275.66 493.12 Tm 0.0022 Tc 0 Tw (27)Tj 10 0 0 10 283.1 490.12 Tm 0 Tc (,)Tj -23.508 -1.32 TD 0.0066 Tc -0.0612 Tw [(1990\). A CA induz um EP do tipo no)-41.4(-neurognico)]TJ T* 0.0114 Tc 0 Tw (\(Louis et al.)Tj 6 0 0 6 105.26 466.72 Tm 0.0022 Tc (18)Tj 10 0 0 10 112.7 463.72 Tm 0.0115 Tc -0.0014 Tw (, 1989\). Apesar da injeo de CA na)Tj -6.468 -1.32 TD 0.0113 Tc 0.0637 Tw [(A)52.3(TM de ratos no ser relatada na literatura, sua)]TJ T* -0.003 Tc -0.0608 Tw (administrao em tecidos superficiais, como a pata)Tj T* 0.0177 Tc 0.285 Tw (de ratos \(Garcia-Leme et al.)Tj 6 0 0 6 195.86 427.12 Tm 0 Tc 0 Tw (9)Tj 10 0 0 10 199.58 424.12 Tm 0.0178 Tc 0.285 Tw (, 1973; Zanin &)Tj -15.156 -1.32 TD 0.0105 Tc 0 Tw [(F)80.3(erreira)]TJ 6 0 0 6 86.66 413.92 Tm 0.0022 Tc (29)Tj 10 0 0 10 94.1 410.92 Tm 0.0121 Tc -0.0575 Tw (, 1978\), resulta em um EP cujo pico m-)Tj -4.608 -1.32 TD 0.0119 Tc 0.0311 Tw [(ximo atingido cerca de 60 minutos aps a inje)-36.1(-)]TJ T* 0.01 Tc -0.0608 Tw (o. Nossos resultados demonstram que a injeo)Tj T* 0.0117 Tc -0.0594 Tw (de CA em tecido orofacial profundo causa EP cujo)Tj T* 0.012 Tc 0.0558 Tw (pico tambm ocorre aps 60 minutos da injeo)Tj T* 0.0114 Tc 0.0638 Tw (de CA 100 g/50 L, o que corrobora resultados)Tj T* 0.0119 Tc -0.0413 Tw (da literatura em tecidos superficiais.)Tj 1.704 -1.332 TD 0.1378 Tw (Injees de CA 1% em tecidos superficiais e)Tj -1.704 -1.32 TD 0.0115 Tc 0.094 Tw (profundos podem causar uma reao inflamat-)Tj 0 -1.332 TD 0.0075 Tc -0.06 Tw (ria \(Gardner)Tj 6 0 0 6 108.02 294.88 Tm 0.0022 Tc 0 Tw (10)Tj 10 0 0 10 115.46 291.88 Tm 0.009 Tc -0.06 Tw (, 1960; Doherty & Robinson)Tj 6 0 0 6 248.78 294.88 Tm 0 Tc 0 Tw (3)Tj 10 0 0 10 252.5 291.88 Tm 0.0095 Tc -0.065 Tw (, 1975;)Tj -20.448 -1.332 TD 0.0111 Tc -0.0169 Tw [(Zanin & F)83.1(erreira)]TJ 6 0 0 6 129.02 281.56 Tm 0.0022 Tc 0 Tw (29)Tj 10 0 0 10 136.46 278.56 Tm 0.0125 Tc -0.0188 Tw (, 1978; Nantel et al.)Tj 6 0 0 6 231.38 281.56 Tm 0.0022 Tc 0 Tw (19)Tj 10 0 0 10 238.82 278.56 Tm 0.0115 Tc -0.02 Tw (, 1999\). A)Tj -19.08 -1.332 TD 0.0119 Tc -0.0433 Tw (CA tem caractersticas especficas como um agen-)Tj T* 0.1372 Tw (te flogstico; no antignica, no causa efeitos)Tj 0 -1.32 TD 0.0083 Tc -0.0607 Tw (sistmicos e tem um alto grau de reprodutividade.)Tj T* 0.0013 Tc -0.061 Tw [(Alm do mais, W)25.3(inter et al.)]TJ 6 0 0 6 173.42 228.52 Tm 0.0022 Tc 0 Tw (28)Tj 10 0 0 10 180.74 225.52 Tm 0.0008 Tc -0.0617 Tw [( \(1962\), relataram que)]TJ -13.272 -1.32 TD 0.0117 Tc 0.058 Tw (doses nicas de antiinflamatrios eram suficien-)Tj T* -0.0257 Tw [(tes para minimizar a inflamao causada por CA)-24.4(,)]TJ T* -0.055 Tw (e Otternes & Moore)Tj 6 0 0 6 140.9 188.92 Tm 0.0022 Tc 0 Tw (22)Tj 10 0 0 10 148.34 185.92 Tm 0.0115 Tc -0.055 Tw [( \(1988\) citaram que as doses)]TJ -10.032 -1.32 TD 0.016 Tc 0.1525 Tw (de antiinflamatrios no esteroidais requeridas)Tj T* 0.0116 Tc -0.0039 Tw (para inibir o edema de pata induzido por CA tm)Tj T* -0.0608 Tw (se correlacionado bem com as doses clinicamente)Tj T* 0.0119 Tc 0.0121 Tw (teis no homem. Julgamos que isto poderia sim-)Tj T* 0.0525 Tw [(plificar procedimentos experimentais, por forne)-36.1(-)]TJ T* 0.0117 Tc 0.02 Tw (cer reprodutividade em um menor curso de tem-)Tj T* -0.0217 Tw (po para as anlises.)Tj 27.78 68.316 TD 0.0176 Tc 0.2171 Tw (Apesar do EP induzido pela injeo de CA)Tj -1.692 -1.296 TD 0.0116 Tc 0.0679 Tw (100 g/50 L ter sido significante comparado ao)Tj 0 -1.284 TD 0.0118 Tc 0.0042 Tw (seu respectivo controle \(salina 0,9%\), anlises de)Tj 0 -1.296 TD 0.0162 Tc 0.1525 Tw (comparao mltiplas \(teste de Dunn\) entre as)Tj 0 -1.284 TD 0.0164 Tc 0.153 Tw (diferentes concentraes utilizadas \(100, 300 e)Tj 0 -1.296 TD 0.0117 Tc -0.0586 Tw (450 g/50 L\) mostraram que somente as concen-)Tj 0 -1.284 TD 0.018 Tc 0.3025 Tw (traes de 300 e 450)Tj 7 0 0 10 423.62 699.28 Tm 0 Tc 0 Tw ( )Tj 10 0 0 10 427.94 699.28 Tm 0.0183 Tc 0.305 Tw (g so estatisticamente)Tj -11.904 -1.296 TD 0.009 Tc -0.0612 Tw (significantes \(p < 0,05\) em relao ao controle. As)Tj 0 -1.284 TD 0.0117 Tc -0.0527 Tw (concentraes de 300 e 450 g so diferentes de)Tj 0 -1.296 TD 0.0118 Tc 0.0043 Tw [(100 g)35.8(, porm no diferem entre si. A concentra-)]TJ 0 -1.284 TD 0.0117 Tc -0.0383 Tw (o de 300 g/50 L foi selecionada para o estudo)Tj 0 -1.296 TD 0.0167 Tc 0.1528 Tw (das drogas antiinfamatrias, pelo fato de ser a)Tj 0 -1.284 TD -0.0022 Tc -0.0607 Tw (menor concentrao a diferir do controle, pela an-)Tj 0 -1.296 TD 0.012 Tc 0.0314 Tw (lise de comparao mltipla. Isto pode ser expli-)Tj 0 -1.284 TD 0.0117 Tc 0.1164 Tw (cado pelo alto desvio padro, que poderia estar)Tj 0 -1.296 TD 0.0115 Tc 0.068 Tw (relacionado dificuldade tcnica de administrar)Tj 0 -1.284 TD -0.0422 Tw [(substncias na regio da A)71.6(TM de ratos. Dificulda-)]TJ 0 -1.296 TD 0.018 Tc 0.1742 Tw [(de esta tambm relatada por F)30(iorentino et al)]TJ /TT10 1 Tf 23.112 0 TD 0 Tc 0 Tw (.)Tj /TT1 1 Tf 6 0 0 6 543.26 560.32 Tm (8)Tj 10 0 0 10 308.9 544.48 Tm 0.0117 Tc (\(1999\).)Tj 1.692 -1.296 TD 0.0118 Tc 0.0366 Tw [(O acesso A)47.8(TM de ratos restrita tanto pelo)]TJ -1.692 -1.284 TD 0.0117 Tc 0.0565 Tw [(pequeno tamanho da regio quanto por sua par)47.7(-)]TJ 0 -1.296 TD 0.012 Tc 0.1057 Tw (cial obstruo pelo arco zigomtico, o que pode)Tj 0 -1.284 TD 0.0116 Tc 0.0537 Tw (resultar em uma variao do local da puno da)Tj 0 -1.296 TD 0.012 Tc 0.0208 Tw [(agulha entre os experimentos. Esta limitao po)-24(-)]TJ 0 -1.284 TD 0.0117 Tc 0.0175 Tw [(deria explicar a variabilidade encontrada no pre)-24.3(-)]TJ 0 -1.296 TD 0.0058 Tc -0.0608 Tw [(sente estudo, particularmente, com relao mag)29.8(-)]TJ 0 -1.284 TD 0.0112 Tc -0.0225 Tw [(nitude do EP na regio da A)59.2(TM.)]TJ 1.692 -1.296 TD 0.0176 Tc 0.4057 Tw [(O pr-tratamento com DEX)17.6(A na dose de)]TJ -1.692 -1.284 TD 0.0115 Tc -0.0106 Tw (2,3 mg/kg no foi capaz de reduzir o EP induzido)Tj 0 -1.296 TD 0.0118 Tc 0.0156 Tw (pela injeo de 300 g/50 L do agente flogstico,)Tj 0 -1.284 TD -0.06 Tw (ou seja, CA 0,6% no tempo de 60 minutos. Apesar)Tj 0 -1.296 TD 0.0117 Tc 0.0808 Tw [(de usarmos uma concentrao dez vezes menor)119.7(,)]TJ 0 -1.284 TD 0.0035 Tc -0.061 Tw (nossos resultados corroboram aqueles obtidos em)Tj 0 -1.296 TD 0.0117 Tc 0.0062 Tw (estudos prvios \(Swift et al.)Tj 6 0 0 6 442.94 353.92 Tm 0.0022 Tc 0 Tw (24)Tj 10 0 0 10 450.38 350.92 Tm 0.0119 Tc 0.0062 Tw (, 1998\), nos quais a)Tj -14.148 -1.284 TD 0.0175 Tc 0.2033 Tw [(DEX)29.5(A na dose de 3 mg/kg no foi eficaz para)]TJ 0 -1.296 TD 0.0118 Tc -0.0464 Tw (minimizar a liberao de PGE2 no processo infla-)Tj 0 -1.284 TD 0.0117 Tc 0.0463 Tw [(matrio induzido pela injeo de CA 6% na A)59.7(T)8.8(M)]TJ 0 -1.296 TD 0.0178 Tc 0.195 Tw (de coelhos. Contudo, quando utilizamos doses)Tj 0 -1.284 TD 0.0116 Tc 0.0456 Tw [(mais altas \(4,6 e 6,9 mg/kg\), esta droga pde re)-24.4(-)]TJ 0 -1.296 TD 0.0306 Tw [(duzir o EP induzido pela CA)-12.3(, comparado ao pr-)]TJ 0 -1.284 TD 0.012 Tc -0.035 Tw (tratamento com o controle salina 0,9%.)Tj 1.692 -1.296 TD -0.0082 Tc -0.0394 Tw [(O pr-tratamento com MEL na dose de 7 mg/kg)27.8(,)]TJ -1.692 -1.284 TD 0.0117 Tc -0.0393 Tw (indicada para o estudo dos efeitos deste antiinfla-)Tj 0 -1.296 TD -0.0083 Tc -0.023 Tw (matrio em ratos \(Engelhardt et al.)Tj 6 0 0 6 471.62 224.92 Tm 0 Tc 0 Tw (6)Tj 10 0 0 10 475.1 221.92 Tm (,)Tj 6 0 0 6 478.1 224.92 Tm ( )Tj 10 0 0 10 479.78 221.92 Tm -0.009 Tc (1995\), )Tj 3.312 0 TD 0.0112 Tc -0.025 Tw [(no re)-36.8(-)]TJ -20.4 -1.284 TD 0.0117 Tc -0.0195 Tw (duziu o EP induzido pela injeo de 300 g/50 L)Tj 0 -1.296 TD 0.0087 Tc -0.0612 Tw [(de CA)-15.3(, no tempo de 60 minutos. Contudo, quando)]TJ 0 -1.284 TD 0.0099 Tc (doses mais altas \(14 e 21 mg/kg\) foram utilizadas,)Tj 0 -1.296 TD 0.0118 Tc -0.018 Tw (o EP foi significativamente diminudo comparado)Tj 0 -1.284 TD 0.012 Tc -0.0333 Tw (ao controle \(salina 0,9%\).)Tj 1.692 -1.296 TD 0.0177 Tc 0.237 Tw (O presente trabalho demonstrou que tanto)Tj -1.692 -1.284 TD 0.0117 Tc -0.0274 Tw [(antiinflamatrios esterioidais \(DEX)23.7(A\) quanto no)]TJ 0 -1.296 TD -0.0058 Tw (esterioidais \(MEL\) minimizam o EP induzido por)Tj 0 -1.284 TD 0.0565 Tw (CA em tecidos orofaciais profundos, o que havia)Tj 0 -1.296 TD 0.0179 Tc 0.165 Tw (sido demonstrado somente em tecidos superfi-)Tj ET endstream endobj 42 0 obj << /ProcSet [/PDF /Text ] /Font << /TT1 4 0 R /TT2 5 0 R /TT3 6 0 R /TT8 11 0 R /TT10 13 0 R >> /ExtGState << /GS1 14 0 R >> /ColorSpace << /Cs6 15 0 R >> >> endobj 44 0 obj << /Length 12173 >> stream /Cs6 CS 0 0 0 SCN 0 J 0 j 0.48 w 10 M []0 d /GS1 gs 1 i 48.02 75.04 m 546.98 75.04 l S BT /TT3 1 Tf 8 0 0 8 238.7 64 Tm /Cs6 cs 0 0 0 scn 0.015 Tc 0.0208 Tw (Revista Odonto Cincia )Tj /TT2 1 Tf 11.205 0 TD 0.0145 Tc [( Fac. Odonto/PUCRS, v. 20, n. 50, out./dez. 2005 )]TJ /TT1 1 Tf 10 0 0 10 528.38 64 Tm 0.0167 Tc 0 Tw (359)Tj /TT3 1 Tf 8 0 0 8 48.02 802.72 Tm 0.0139 Tc 0.0375 Tw (Efeito da dexametasona e do meloxicam sobre ...)Tj /TT2 1 Tf 42.57 0 TD 0.0154 Tc 0.0279 Tw [(Boleta-Ceranto DCF)120.4(, V)60.4(eiga MCF)45.4(A, Arsati F)]TJ /TT1 1 Tf 10 0 0 10 48.02 776.6801 Tm 0.0125 Tc 0.1533 Tw [(ciais \(V)36.5(inegar et al.)]TJ 6 0 0 6 144.74 779.6801 Tm 0.0022 Tc 0 Tw (26)Tj 10 0 0 10 152.18 776.6801 Tm 0 Tc (,)Tj 6 0 0 6 155.3 779.6801 Tm ( )Tj 10 0 0 10 158.18 776.6801 Tm 0.0126 Tc 0.1551 Tw [(1976; Zanin & F)96.6(erreira)]TJ 6 0 0 6 275.66 779.6801 Tm 0.0022 Tc 0 Tw (29)Tj 10 0 0 10 283.1 776.6801 Tm 0 Tc (,)Tj -23.508 -1.284 TD 0.0118 Tc 0.075 Tw (1978; Henriques et al.)Tj 6 0 0 6 158.42 766.84 Tm 0.0022 Tc 0 Tw (13)Tj 10 0 0 10 165.86 763.84 Tm 0 Tc (,)Tj /TT10 1 Tf 0.324 0 TD ( )Tj /TT1 1 Tf 0.384 0 TD 0.012 Tc 0.075 Tw (1987; Donnerer et al.)Tj 6 0 0 6 279.38 766.84 Tm 0 Tc 0 Tw (4)Tj 10 0 0 10 283.1 763.84 Tm (,)Tj -23.508 -1.284 TD 0.0033 Tc -0.06 Tw (1991; Nantel)Tj 6 0 0 6 108.86 754 Tm 0.0022 Tc 0 Tw (19)Tj 10 0 0 10 116.3 751 Tm 0.0025 Tc -0.06 Tw (, 1999; Amann & Schuligou)Tj 6 0 0 6 246.02 754 Tm 0 Tc 0 Tw (2)Tj 10 0 0 10 249.74 751 Tm 0.0025 Tc -0.065 Tw (, 2000\).)Tj -20.172 -1.284 TD 0.0118 Tc -0.0071 Tw (Mas, em ambos os casos, os agentes teraputicos)Tj 0 -1.296 TD 0.0104 Tc -0.0607 Tw (somente foram eficazes em doses duas vezes mais)Tj 0 -1.284 TD 0.0119 Tc -0.029 Tw (altas do que as habitualmente utilizadas.)Tj 1.704 -1.296 TD 0.0117 Tc -0.0166 Tw (A maioria dos antiinflamatrios no seletiva)Tj -1.704 -1.284 TD -0.005 Tw [(para a cicloxigenase)-36.3(-1 \(CO)35.7(X)33.5(-1\) e para a cicloxige)-36.3(-)]TJ 0 -1.296 TD 0.0099 Tc -0.0596 Tw [(nase)-50.1(-2 \(CO)45.9(X)31.7(-2\) \(Insel)]TJ 6 0 0 6 150.02 676.6 Tm 0.0022 Tc 0 Tw (16)Tj 10 0 0 10 157.46 673.6 Tm 0.0109 Tc -0.061 Tw (, 1995\). Contudo, o MEL, )Tj -10.944 -1.284 TD 0.012 Tc 0.0768 Tw [(trs vezes mais seletivo para a CO)36(X)33.8(-2 e tambm)]TJ 0 -1.296 TD 0.0115 Tc -0.0067 Tw (no interfere com a produo de prostaglandinas)Tj 0 -1.284 TD 0.0078 Tc -0.061 Tw (envolvidas em processos fisiolgicos, que regulam)Tj 0 -1.296 TD 0.0118 Tc 0.1529 Tw (a atividade celular normal, dessa forma o MEL)Tj 0 -1.284 TD 0.0003 Tc -0.06 Tw [(causa menos efeitos colaterais \(V)108.3(ane et al.)]TJ 6 0 0 6 242.66 612.16 Tm -0.0178 Tc 0 Tw (25)Tj 10 0 0 10 249.86 609.16 Tm -0.0009 Tc -0.065 Tw (, 1995\).)Tj -18.48 -1.296 TD 0.0116 Tc -0.0291 Tw [(P)41.8(or outro lado, os corticosterides so drogas)]TJ -1.704 -1.284 TD 0.0086 Tc -0.061 Tw (antiinflamatrias mais eficazes melhores e inibem)Tj 0 -1.296 TD 0.0118 Tc 0.0493 Tw (de uma maneira no seletiva a reao inflamat-)Tj 0 -1.284 TD 0.0265 Tw (ria, contudo, os efeitos colaterais por eles causa-)Tj 0 -1.296 TD 0.0572 Tw [(dos, limitam o seu uso. A DEX)11.9(A inibe a induo)]TJ 0 -1.284 TD 0.0116 Tc 0.0459 Tw [(de lipocortina-1, CO)35.6(X)33.4(-2, iNOS e citocinas \(IL)-24.4(-1)]TJ /F4 1 Tf 22.944 0 TD 0 Tc 0 Tw ()Tj /TT1 1 Tf 0.564 0 TD (,)Tj -23.508 -1.296 TD 0.0133 Tc 0.0297 Tw [(IL)-10.7(-2 e TNF)109.3(-)]TJ /F4 1 Tf 5.496 0 TD 0 Tc 0 Tw ()Tj /TT1 1 Tf 0.648 0 TD 0.0118 Tc 0.0309 Tw (\), que so importantes na reao in-)Tj -6.144 -1.284 TD 0.0125 Tc -0.0266 Tw [(flamatria \(V)108.5(ane et al.)]TJ 6 0 0 6 153.26 508.96 Tm 0.0022 Tc 0 Tw (25)Tj 10 0 0 10 160.7 505.96 Tm 0.0112 Tc -0.03 Tw (, 1995\).)Tj -9.564 -1.296 TD 0.0119 Tc 0.05 Tw [(P)42.1(orm, os efeitos dos anti-inflamatrios este)-36.1(-)]TJ -1.704 -1.284 TD -0.0499 Tw [(roidais e no)-36.2(-)-31.1(esteroidais, utilizados neste modelo)]TJ 0 -1.296 TD -0.0586 Tw (experimental so similares, o que nos permite su-)Tj 0 -1.284 TD 0.0176 Tc 0.1767 Tw (gerir uma predominncia do efeito inibidor da)Tj 0 -1.296 TD 0.0116 Tc -0.0178 Tw [(CO)35.6(X)33.4(-2 pela DEX)11.6(A)-19.4(,)0( e que as prostaglandinas deri-)]TJ 0 -1.284 TD 0.0114 Tc 0.0192 Tw [(vadas da CO)23.4(X)33.2(-2 esto envolvidas no EP induzido)]TJ 0 -1.296 TD 0.0116 Tc -0.0222 Tw [(pela administrao de CA na A)59.6(TM de ratos, o que)]TJ 0 -1.284 TD -0.056 Tw (corrobora estudos clnicos demonstrando um im-)Tj 0 -1.296 TD 0.0005 Tc -0.0608 Tw (portante papel das prostaglandinas em quadros de)Tj 0 -1.284 TD 0.0111 Tc -0.0284 Tw (DTMs \(Quinn et al.)Tj 6 0 0 6 139.58 379.96 Tm 0.0022 Tc 0 Tw (22)Tj 10 0 0 10 147.02 376.96 Tm 0.0117 Tc -0.0283 Tw (, 1990\) e que a prescrio de)Tj -9.9 -1.296 TD 0.0052 Tc -0.0608 Tw [(antiinflamatrios uma teraputica eficaz em pro)-42.8(-)]TJ 0 -1.284 TD 0.0003 Tc (mover analgesia em pacientes portadores de DTMs)Tj 0 -1.296 TD 0.0146 Tc 0.1525 Tw (relacionadas processos inflamatrios \(Ekberg)Tj 0 -1.284 TD 0.0124 Tc -0.02 Tw (et al.)Tj 6 0 0 6 71.54 328.36 Tm 0 Tc 0 Tw (5)Tj 10 0 0 10 75.26 325.36 Tm (,)Tj /TT10 1 Tf 0.312 0 TD ( )Tj /TT1 1 Tf 0.3 0 TD 0.0114 Tc (1996\).)Tj -1.632 -1.296 TD 0.0085 Tc -0.0608 Tw [(Apesar da alta incidncia de condies doloro)-39.5(-)]TJ -1.704 -1.284 TD 0.0113 Tc -0.0465 Tw [(sas da A)47.3(TM estarem associadas a processos infla-)]TJ 0 -1.296 TD 0.0115 Tc -0.015 Tw (matrios na regio, ainda h pouca concordncia)Tj 0 -1.284 TD 0.012 Tc 0.08 Tw (com bases cientficas com relao ao mtodo de)Tj 0 -1.296 TD 0.0178 Tc 0.1691 Tw (tratamento mais adequado para estes casos. A)Tj 0 -1.284 TD 0.012 Tc 0.088 Tw (principal causa do limitado conhecimento sobre)Tj 0 -1.296 TD 0.0118 Tc -0.031 Tw (os mediadores qumicos envolvidos nestas condi-)Tj 0 -1.284 TD 0.012 Tc -0.0186 Tw (es a no existncia de modelos experimentais)Tj 0 -1.296 TD 0.0117 Tc -0.025 Tw (adequados para o estudo destas patologias.)Tj 1.704 -1.284 TD 0.09 Tw (Nossos resultados evidenciam a participao)Tj -1.704 -1.296 TD 0.0115 Tc 0.0237 Tw (das prostaglandinas nos processos inflamatrios)Tj 0 -1.284 TD 0.1292 Tw [(induzidos por CA)-12.4(, demonstrando que o modelo)]TJ 0 -1.296 TD -0.0279 Tw (utilizado por ns pode ser indicado para elucidar)Tj 0 -1.284 TD -0.0037 Tc -0.061 Tw [(os mecanismos neuroqumicos envolvidos nos pro)-39.7(-)]TJ 0 -1.296 TD 0.0104 Tc -0.0608 Tw (cessos inflamatrios de tecidos profundos como a)Tj 0 -1.284 TD 0.0117 Tc 0.145 Tw [(A)52.7(TM, bem como para indicar tratamentos mais)]TJ 0 -1.296 TD -0.0083 Tc -0.0387 Tw (adequados envolvendo antagonistas especficos dos)Tj 0 -1.284 TD -0.0092 Tc -0.0608 Tw (mediadores qumicos presentes em casos de DTMs.)Tj /TT8 1 Tf 9 0 0 9 349.7 777.04 Tm 0.0149 Tc -0.0278 Tw (REFERNCIAS BIBLIOGRFICAS)Tj /TT1 1 Tf -4.5333 -2.0133 TD 0.0146 Tc 0.0667 Tw [( )78.8( )60.5(1.)-305.4(Alder ME, et al. Magnetic resonance spectroscopy)]TJ 1.88 -1.12 TD 0.021 Tc 0.4255 Tw [(of inflammation associated with the temporo)-45.7(-)]TJ T* 0.0148 Tc -0.0057 Tw [(mandibular joint. Oral Surg Oral Med Oral P)28.1(athol.)]TJ T* 0.0155 Tc 0 Tw (1992;74\(4\):515-32.)Tj -1.88 -1.44 TD 0.015 Tc -0.0047 Tw [( )-7.9( )-7.9(2.)-291.7(Amman R, Schuligou R. Inhibition of carrageenan-)]TJ 1.88 -1.12 TD 0.0213 Tc 0.6322 Tw (induced edema by indomethacin or sodium)Tj 0 -1.1333 TD 0.0191 Tc 0.1532 Tw (salicylate does not prevent the increase of nerve)Tj 0 -1.12 TD 0.0148 Tc 0.1341 Tw [(growth factor in the rat hind paw)81.5(. Neurosci Lett.)]TJ T* 0.0155 Tc 0 Tw (2000;3\(278\):173-6.)Tj -1.88 -1.44 TD 0.021 Tc 0.5156 Tw [( )518.4( )518.4(3)5.6(.)-285.7(Doherty NS, Robinson B)21(V)182.3(. The inflammatory)]TJ 1.88 -1.12 TD 0.0145 Tc -0.0472 Tw (response to carrageenan. J Pharm Pharmac. 1975;)Tj T* 0.0153 Tc 0 Tw (27:701-3.)Tj -1.88 -1.44 TD 0.0208 Tc 0.2937 Tw [( )296.3( )296.3(4)5.4(.)-285.9(Donnerer J)74.1(,)-0.4( Amann R, Lembeck F)194.1(.)0.3( Neurogenic)]TJ 1.88 -1.12 TD 0.0158 Tc 0.1528 Tw (and non-neurogenic inflammation in the rat paw)Tj T* 0.0152 Tc 0.1074 Tw [(following chemical sympathectomy)108.5(. Neuroscience.)]TJ 0 -1.1333 TD 0.0154 Tc 0 Tw (1991;45\(3\):761-5.)Tj -1.88 -1.4267 TD 0.0113 Tc -0.0613 Tw [( )-68.2( )-68.2(5.)-295.4(Ekberg EC, K)24.6(oop S, Akerman S. Diclofenac sodium)]TJ 1.88 -1.1333 TD 0.0148 Tc 0.0278 Tw (as an alternative treatment of temporomandibular)Tj 0 -1.12 TD 0.0022 Tw (joint pain. Acta Odontol Scand. 1996;54\(3\):154-9.)Tj -1.88 -1.44 TD 0.015 Tc 0.0592 Tw [( )56( )56(6.)-291.7(Engelhardt G)15(,)1( Homma D)41.7(,)-0.1( Schlegel K, Utzmann R,)]TJ 1.88 -1.12 TD 0.0212 Tc 0.2347 Tw [(Schnitzler C. 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Development of)]TJ 1.88 -1.12 TD 0.0198 Tc 0.1528 Tw (inflammation after application of mustard oil or)Tj T* 0.0208 Tc 0.3489 Tw (glutamate to the rat temporomandibular joint.)Tj T* 0.0149 Tc 0.0093 Tw (Archs Oral Biol. 1999;44\(1\):27-32.)Tj -1.88 -1.44 TD 0.0125 Tc -0.0612 Tw [( )-66.9( )-66.9(9.)-294.2(Garcia-Leme J)65.8(,)0.2( Hamamura L, Leite MP Rocha e Sil-)]TJ 1.88 -1.12 TD 0.0205 Tc 0.4982 Tw (va M. Pharmacological analyses of the acute)Tj 0 -1.1333 TD 0.0151 Tc 0.0673 Tw [(inflammatory process induced in the rat)28.4(s paw by)]TJ 0 -1.12 TD 0.036 Tw [(local injection of carrageenin and by heating)28.4(. Br J)]TJ T* 0.0153 Tc 0 Tw (Pharmac.1973;48:88-96.)Tj -1.88 -1.44 TD 0.015 Tc 0.1069 Tw [(10.)-305(Gardner DL. P)15(roduction of arthritis in the rabbit)]TJ 1.88 -1.12 TD 0.0211 Tc 0.2287 Tw (by the local injection of the mucopolysacharide)Tj T* 0.0155 Tc 0.0129 Tw [(caragheenin. 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/FontDescriptor /Ascent 938 /CapHeight 0 /Descent -261 /Flags 34 /FontBBox [-167 -261 1230 939] /FontName /FGGKIE+BookmanITCLtBT /ItalicAngle 0 /StemV 0 /FontFile2 50 0 R >> endobj 50 0 obj << /Filter /FlateDecode /Length 16338 /Length1 23916 >> stream HtW PU=G-CFF5Xj?1?#Q $JZM26ڌ5Z5J^Ԇ&uZEb,2شv:e}N49{v^0 c#,Bߙ3ޒE+r`h)7%CϔU=\QX5ڇW+nZ{ʗ,}Y.Hp~מx!FAJXY7W_<4We