Mutações de resistência em gestantes infectadas pelo HIV: uma revisão da literatura

Ana Teresa Mancini Pimenta, Silvana Maria Quintana

Resumo


Objetivo: O objetivo desta revisão foi buscar na literatura dados sobre a prevalência de mutações de resistência do HIV aos antirretrovirais em gestantes infectadas pelo vírus.
Materiais e Métodos: A busca e seleção de artigos foi realizada nas bases de dados PubMed, Scielo e Biblioteca Virtual em Saúde sem delimitação de data. Os termos utilizados na busca foram: pregnancy, HIV e drug resistance. 
Resultados: Foram encontrados 47 estudos relacionados ao assunto, realizados em 26 países, publicados no período de 1998 a 2014. A prevalência de resistência transmitida variou de zero a 18% enquanto a resistência adquirida variou de zero a 50% em amostras coletadas entre 1989 e 2013. 
Conclusão: Generalizar os resultados é inviável devido às diferentes características dos estudos. No entanto, o monitoramento contínuo da resistência do HIV aos antirretrovirais em cada localidade é essencial.

 


Palavras-chave


gravidez; HIV; mutação; transmissão vertical de doença infecciosa; resistência a medicamentos.

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Referências


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DOI: http://dx.doi.org/10.15448/1983-652X.2015.3.20327

 

e-ISSN: 1983-652X 

 

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